background: for the first time we tested an association between the human multidrug resistance gene 1 (mdr1) polymorphisms (snps) and idiopathic pulmonary fibrosis (ipf). several mdr1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. materials and methods: we genotyped three mdr1 polymorphisms of 48 ipf patients and 100 control subj...

background: despite the advances in medical therapy and technology, the prognosis of idiopathic pulmonary fibrosis (ipf) remains poor and the need for disease prevention based on identifying the risk factors becomes mandatory. occupational and environmental exposures were studied in several countries and found to play important role in the disease development. however, in egypt, a little attent...

Background: The aim of our study is to investigate the impact simple breathing exercises (LHP’s respiratory rehabilitation for pulmonary fibrosis, LHP’s RRPF) on patients with idiopathic fibrosis (IPF).

Multiple investigators have undertaken genetic studies in idiopathic pulmonary fibrosis populations in attempts to define genetic links to disease in hopes that this would improve understanding of disease pathogenesis and target pathways for therapy. Multiple genes have been evaluated using a candidate gene approach with limited success, with results suggesting a disease modifier effect rather ...

Transplant 1999;18:884e90. 12. Dahele M, Ung Y, Meharchand J, et al. Integrating regional and community lung cancer services to improve patient care. Curr Oncol 2007;14:234e7. 13. Murray SA, Boyd K, Sheikh A. Palliative care in chronic illness. BMJ 2005;330:611e12. 14. Hofer M. Advanced chronic lung disease: need for an active interdisciplinary approach. Swiss Med Wkly 2007;137:593e601. 15. Rag...

"Nondrug Treatments for Idiopathic Pulmonary Fibrosis: IPF Part 3." American Journal of Respiratory and Critical Care Medicine, 203(4), pp. P10–P11

BACKGROUND Acute exacerbations of idiopathic pulmonary fibrosis are major causes of morbidity and mortality among patients with idiopathic pulmonary fibrosis. However, acute exacerbations remain unpredictable. The aim of this study was to investigate risk factors for acute exacerbations of idiopathic pulmonary fibrosis. METHODS We performed a retrospective cohort study of patients with idiopa...

REFERENCES 1 Raghu G, Collard HR, Egan JJ, et al. An Official ATS/ERS/JRS/ ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med 2011; 183: 788–824. 2 du Bois RM. Strategies for treating idiopathic pulmonary fibrosis. Nat Rev Drug Discov 2010; 9: 129–140. 3 Papiris SA, Manali ED, Kolilekas L, et al. Clinical review: idio...

Idiopathic pulmonary fibrosis (IPF) is an incurable condition that is characterized by progressive pulmonary fibrosis, architectural distortion of the lung and loss of gas exchange units. Until recently, there was no effective treatment for this condition. However, there were two landmark trials published earlier this year, which have changed the management of this condition. Pirfenidone (Asses...

BACKGROUND Immunosuppressive therapy has been-until the recent release of new guidelines on diagnosis and management-the recommended treatment for idiopathic pulmonary fibrosis. However, its efficacy in patients with idiopathic pulmonary fibrosis has always been a matter of debate. CASE PRESENTATION We report the occurrence of idiopathic pulmonary fibrosis in a white man receiving chronic imm...