conclusions our results show that oxidative stress could play an important role in male infertility as well as in sperm motility and sperm morphology. patients and methods this case control study was conducted using 35 men with idiopathic infertility and 34 men with proven fertility. seminal plasma tac and mda were measured by ferric reducing ability of plasma (frap) and thiobarbituric acid (tb...

conclusions the weakness of the literature with regard to coenzyme q10 is about its effects in patients with severely diminished sperm densities and the physiologic steps of morphologic improvements. results the increase in mean values of concentration after the ubiquinol treatment was not statistically significant (p value = 0.065). however, the changes in morphology and motility (fast progres...

INTRODUCTION To compare the semen quality score and the seminal oxidative stress reactive oxygen species (ROS) and total antioxidant capacity (ROS-TAC score) in men with idiopathic infertility with normal donors and to a known group of fertile and infertile men. MATERIAL AND METHODS Principal component analysis was applied to provide a standardized score in 36 men with idiopathic infertility ...

background: pentoxifylline (px) is a methyl xanthine derivative that influences the sperm motion characteristics and l-carnitine (l-c) is an amino acid that is naturally produced in the body. in general, separate administration of px and l-c has been reported to be effective on preserving sperm motility in vitro, and also when is consumed orally by the idiopathic oligoasthenoteratozoospermia (i...

INTRODUCTION Infertility affects approximately 15% of all couples, and male factor contribute to up to 50% of cases. Unfortunately, the cause of male infertility is unknown in about 30% of these cases. Infertility of unknown origin is classified as idiopathic male infertility when abnormal semen parameters are present. Despite not having a definable cause, these men may respond to treatment. Th...

In this study, we investigated the association between six genetic polymorphisms (MTHFR C677T and A1298C, NFKB1 -94ins/del ATTG, NFKBIA 3’UTR A>G, DAZL A386G (T54A) and CYP1A1 T3801C) and the risk of idiopathic male infertility in a Chinese population. A case-control study comprising 1,759 idiopathic male infertile patients of Han Chinese ethnicity and 1,826 healthy fertile control individuals ...

Human Andrology 2011, 1:2–16 Objective To highlight the concept of unexplained male infertility and discuss the potential causes and its proper management. Design Review of literature. Results Male infertility of unknown origin is a condition in which fertility impairment occurs spontaneously or due to an obscure or unknown cause. It includes two categories, unexplained male infertility and idi...

BACKGROUND Abnormal germline DNA methylation in males has been proposed as a possible mechanism compromising spermatogenesis of some men currently diagnosed with idiopathic infertility. Previous studies have been focused on imprinted genes with DNA methylation in poor quality human sperms. However, recent but limited data have revealed that sperm methylation abnormalities may involve large numb...

This study examined the relationship between demographic features and aetiological causes of male infertility. Primary infertility was the presentation in 78% of patients. The incidence of varicocele was the highest (31%), whereas only 4.6% had vasectomy reversal and 7.4% of men were diagnosed with idiopathic infertility. Using the chi-squared test, there was no significant difference in the in...

Meta-analysis Polymorphism Studies of the relationship between male infertility and CYP1A1 polymorphisms are inconclusive. To drive a more precise estimation, we performed a meta-analysis based on 1,060 cases and 1,225 controls from 7 published casecontrol studies. PubMed and CNKI literature search were conducted to identify all eligible studies investigating such a relationship. Crude odds rat...