Inhibition of ovulation by RMI 12,936 was associated with suppression of the pro-oestrous peak of hypothalamic dopamine. The antiovulatory effect was not reversed by administration of oestrogen, was partly reversed by progesterone and was fully reversed by oestrogen and progesterone. Hypophysial sensitivity to LH-RH, known to be reduced by RMI 12,936, remained low when ovulation was restored by...

The hypophysial stalk of the horse had a typical structure of the median eminence and contained noradrenaline, dopamine, serotonin, vasopressin and paraldehyde fuchsine-stainable material. The posterior wall of the hypophysial stalk contained higher concentration of noradrenaline than the anterior and lateral walls. On the other hand, the anterior and lateral walls contained dopamine but the po...

A 29 year old female with a chiasmal syndrome secondary to a Rathke's cleft cyst is described. The histology and pathogenesis of these rare cysts are discussed, contrasting them with other hypophysial cysts.

The brains from 14 adult common tree shrews (Tupaia glis) of both sexes were used for the study of hypothalamic blood supply. It is found that the hypothalamus is supplied by branches of arteries that form the circle of Willis. The preoptic region of the anterior hypothalamus is supplied by branches of anterior cerebral and anterior communicating arteries, while branches of the ophthalmic, ante...

Geoffrey Harris, while still a medical student at Cambridge, was the first researcher (1937) to provide experimental proof for the then tentative view that the anterior pituitary gland was controlled by the CNS. The elegant studies carried out by Harris in the 1940s and early 1950s, alone and in collaboration with John Green and Dora Jacobsohn, established that this control was mediated by a ne...

Presurgical diagnosis requires the collaboration of a medical team including the attending physician, the endocrinologist, the radiologist and the ophthalmologist. It includes the pituitary hormonal levels certifying the secretory or non-secretory character of the tumour, the neuroradiological aspect with triplanar MRI T1WI, T2WI and with gadolinium injection. In conclusion, hormonal and neuror...