Objective: To determine the frequency of various metabolic abnormalities in children with urinary lithiasis. Methods: This cross-sectional study was conducted at Armed Forces Institute Urology, Rawalpindi, from 30 January 2017 to 1 February 2020. A total 1355 who were aged 4 14 years and had renal stones included, while those tract infections, posterior urethral valve, pelvi-ureteric junction o...

in spite of vast improvements in urinary stone treatment (eswl, pnl, ureteroscopy, etc.), metabolic workup concerning the existence of stone forming risk factors are of great importance and can lead to control and even prevention of urinary stone formation in these patients. in this analytical case-control study performed on 266 persons [110 normal persons (56 males and 54 females), 76 patients...

The body maintains Mg(2+) homeostasis by renal and intestinal (re)absorption. However, the molecular mechanisms that mediate transepithelial Mg(2+) transport are largely unknown. Transient receptor potential melastatin 6 (TRPM6) was recently identified and shown to function in active epithelial Mg(2+) transport in intestine and kidney. To define the relationship between Mg(2+) status and TRPM6 ...

Measurements of serum and urinary magnesium levels were made together with the other electrolytes, haematocrit, pH, and albumin in patients comprising two groups-one group of 50 patients undergoing heart valve replacement, and the other, 30 patients undergoing non-perfusion thoracic operations. Low serum magnesium levels were found in some patients admitted to hospital who were or had recently ...

INTRODUCTION Metabolic investigation in patients with urinary lithiasis is very important for preventing recurrence of disease. The objective of this work was to diagnose and to determine the prevalence of metabolic disorders, to assess the quality of the water consumed and volume of diuresis as potential risk factors for this pathology. PATIENTS AND METHODS We studied 182 patients older than...

INTRODUCTION Urinary calculi in infants are relatively infrequent, but their incidence has increased in the recent decades. The aim of this study was to investigate the clinical presentation, metabolic risk factors, and urinary tract abnormalities in infants suffering from kidney calculus. MATERIALS AND METHODS A total of 152 infants were admitted between 2009 and 2012 with ultrasonography-pr...

Sudden Unexplained Death Syndrome (SUDS) is a major health problem in rural residents of Northeast Thailand. The cause of death in SUDS is suspected to be cardiovascular abnormalities. As magnesium (Mg) and zinc (Zn) deficiency contribute significantly to several cardiovascular diseases, we investigated the Mg- and Zn-status of patients with sudden respiratory distress and cardiac arrest who ha...

Hyperaldosteronism is associated with hypertension, cardiovascular fibrosis, and electrolyte disturbances, including hypomagnesemia. Mechanisms underlying aldosterone-mediated Mg(2+) changes are unclear, but the novel Mg(2+) transporters TRPM6 and TRPM7 may be important. We examined whether aldosterone influences renal TRPM6/7 and the TRPM7 downstream target annexin-1 and tested the hypothesis ...

Dear Editor, Nephrolithiasis is a common urinary problem with a worldwide estimated prevalence rate of 4–20% and a 5-year recurrence rate of 50%. It accounts for significant expense and morbidity. Recurrent stone disease is a major cause of end-stage renal disease, which may eventually lead to renal transplantation. The prevalence rate of stone disease, in the Middle East region and in Iran, is...