background & objective:  periodic paralyses are a group of rare disorders that cause temporary episodes of muscle weakness or paralysis.  hypokalemic periodic paralysis usually is transmitted by an autosomal dominant trait with more penetration in men.  hypokalemic periodic paralysis may be secondary to thyrotoxicosis, hyperparathyroidism, drug  toxicity and potassium losing states. sporadic fo...

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Acute hypokalemic paralysis is a rare cause of acute weakness. Morbidity and mortality associated with unrecognized disease can occur and include respiratory failure and possibly death. Common causes of hypokalemic paralysis include thyrotoxic periodic paralysis (TPP) which is a disorder most frequently seen in Asian males. TPP is characterized by sudden onset of hypokalemia and paralysis that ...

An 8-year-old boy with familial hypokalemic periodic paralysis is described. Twenty eight cases of periodic paralysis under 15 years of age were collected from the Japanese literature and reviewed. Serum potassium concentrations during an attack of paralysis were recorded in 27 cases including our case: 20 cases were hypokalemic, 4 were normokalemic and 3 were hyperkalemic. Hypokalemic periodic...

OBJECTIVE To study the clinical characteristics of patients who suffer from hypokalemic periodic paralysis, as the presenting symptoms of thyrotoxicosis. MATERIAL AND METHOD A retrospective review of 29 patients who presented with the syndrome of hypokalemic periodic paralysis as the symptom of thyrotoxicosis at Ratchaburi Hospital between January 1,1995 and December 31, 2007. Patients'data, ...

Rhabdomyolysis continues to appear with increasing frequency and represents a medical emergency requiring rapid appropriate treatment. One of the unusual causes of nontraumatic rhabdomyolysis is hypokalemic periodic paralysis without secondary causes. Primary hypokalemic periodic paralysis is a rare genetic disease characterized by episodic attacks of muscle weakness due to decreases in serum p...

Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare complication of hyperthyroidism and an uncommon form of hypokalemic periodic paralysis. Its differentiation of more common forms of periodic paralysis is important because aggressive treatment can place the patient at risk for rebound hyperkalemia. Treatment of the underlying thyroid dysfunction cures the muscle symptoms. Here we descri...

This article focuses on questions that arise about diagnosis and treatment for people with hypokalemic periodic paralysis. We will focus on the familial form of hypokalemic periodic paralysis that is due to mutations in one of various genes for ion channels. We will only briefly mention other �secondary� forms such as those due to hormone abnormalities or due to kidney disorders that result in ...

Thyrotoxic periodic paralysis is a unique disorder that causes episodic proximal lower extremity muscle weakness in patient who already has hyperthyroid state and not treated for the underlying disease state. The affected population mostly includes Asian origin specifically male gender (vs most thyroid affects women gender). Precipitating factors include addition to are strenuous exertion, high...