OBJECTIVE Recent dietary trials and observational studies have focused on the effects of diet on health outcomes such as improvement in levels of surrogate biomarkers. The aim of our study was to examine the changes in weight, adipocytokines levels and insulin resistance after a high-protein/low carbohydrate hypocaloric diet vs. a standard hypocaloric diet during an intervention of 9 months. ...

OBJECTIVE Hyperaminotransferasemia is an important problem in obese patients. We decide to examine the changes in hyperaminotransferasemia after weight reduction in obese patients with and without NAFLD secondary to a high monounsaturated fat vs. a high polyunsaturated fat hypocaloric diets. PATIENTS AND METHODS A population of 306 obese patients was randomly allocated to two groups: Diet M (...

INTRODUCTION common polymorphisms (rs9939609) of the fat mass and obesity associated gene (FTO) have been linked to obesity. OBJECTIVES our aim was to investigate the role of this polymorphism on insulin resistance, metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diets. MATERIAL AND METHODS a sample of 233 obese subjects wa...

Background: The SNP of the leptin receptor (Lys656Asn) has been related with metabolic parameters. The aim of our design was to evaluate the influence of Lys656Asn variant of Leptin receptor gene on weight loss and metabolic parameters secondary to a high protein/low carbohydrate vs. a standard hypocaloric diets. Design: A total of 280 obese subjects were randomly allocated to one of two diets ...

background: identifying new ways to decrease adiposity will be very valuable for health. the aim of this study was to find out whether l-arginine (arg) and selenium alone or together can increase the effect of hypocaloric diet enriched in legumes (hdel) on anthropometric measures in healthy obese women. methods: this randomized, double-blind, placebo-controlled trial was undertaken in 84 health...

Calorie restriction is a common strategy for weight loss and management. Consumption of food and nutrients stimulates diet-induced thermogenesis (DIT), as well as pancreatic and gastrointestinal hormone secretion that may regulate energy metabolism. Yet, little is known about the impact of hypocaloric diets on energy metabolism-related parameters. In this study, we assessed the effects of hypoc...

background: the effect of high‑legume hypocaloric diet on metabolic features in women is unclear. this study provided an opportunity to find effects of high‑legume diet on metabolic features in women who consumed high legumes at pre‑study period. methods: in this randomized controlled trial after 2 weeks of a run‑in period on an isocaloric diet, 42 premenopausal women with central obesity were ...

Background and aim: The C385A polymorphism of FAAH gene (rs324420C>A) has been associated with obesity. We investigate the role of this polymorphism on cardiovascular risk factors and weight loss secondary to a high protein/ low carbohydrate vs. a standard hypocaloric diets (1000 kcal/day) during 9 months. Methods: A sample of 284 subjects with obesity (body mass index (BMI) >30) was enrolled. ...

BACKGROUND The effect of legume-based hypocaloric diet on cardiovascular disease (CVD) risk factors in women is unclear. This study provides an opportunity to find effects of high-legume diet on CVD risk factors in women who consumed high legumes at baseline. METHODS This randomized controlled trial was undertaken in 34 premenopausal women with central obesity. After 2 weeks of a run-in perio...

OBJECTIVE Apelin is a novel adipokine acting on APJ receptor, regulated by insulin and tumor necrosis factor-alpha (TNF-alpha) in adipose tissue (AT). Plasma apelin levels are increased in obese hyperinsulinemic subjects. The aim was to investigate whether the hypocaloric diet associated with weight loss modifies the elevated plasma apelin levels and the expression of apelin and APJ receptor in...