Abstract Aim Hypocalcaemia is a frequent, and potentially dangerous, complication of total thyroidectomy [1, 2] due to the removal parathyroid glands. This quality improvement (QI) project was undertaken in large Ear, Nose Throat department East England over year. The improved postoperative guideline compliance by optimising recognition management patients at risk hypocalcaemia. process focusse...

Background: Jaundice is one of the most common problems occurring in the neonatal period. It is commonly managed by phototherapy with its inherent complications. However, this treatment modality may itself result in the development of hypocalcaemia and create serious complications including convulsion and related conditions. Objective: To determine the effect of phototherapy on serum calcium le...

BACKGROUND 22q11.2 deletion syndrome (22q11.2DS) is a relatively common yet under-recognized genetic syndrome that may present with endocrine features. We aimed to address the factors that contribute to the high prevalence of hypocalcaemia. METHODS We investigated hypocalcaemia in a well-characterized sample of 138 adults with 22q11.2DS (65 m, 73 F; mean age 34.2, SD 11.8, years) using labora...

maternal vitamin d deficiency is one of the major risk factors for neonatal vitamin d deficiency followed by neonatal hypocalcaemia. the aim of this study is to determine the relationship between delayed neonatal hypocalcaemia and maternal vitamin d deficiency. this is a descriptive cross-sectional study. target population of this study included all term and preterm neonates with delayed hypoca...

Hypocalcaemia is common in severely-malnourished children and is often associated with fatal outcome. There is very limited information on the clinical predicting factors of hypocalcaemia in hospitalized severely-malnourished under-five children. Our objective was to evaluate the prevalence, clinical predicting factors, and outcome of hypocalcaemia in such children. In this case-control study, ...

A severely thyrotoxic patient was found to have hypocalcaemia and tetany, which cleared when she became euthyroid. Cessation of treatment with propranolol and propylthiouracil resulted in a recurrence of the thyrotoxicosis and the reappearance of hypocalcaemia. Reinstitution of treatment resulted in a second remission of the thyrotoxicosis and correction of the hypocalcaemia. It is suggested th...

INTRODUCTION Hypocalcaemia, although usually transitory, is the most frequent complication after total thyroidectomy. OBJECTIVE To identify factors associated with a higher risk of hypoparathyroidism and related to aetiology and surgical procedure. MATERIALS AND METHODS A total of 254 total thyroidectomies were analysed for the incidence of transitory or permanent hypocalcaemia based on the...

OBJECTIVE To evaluate whether perioperative PTH levels or ionized calcium levels are associated with symptomatic hypocalcaemia, in patients undergoing parathyroidectomy for primary hyperparathyroidism. STUDY DESIGN Prospective noncontrolled study of a cohort of 100 patients, undergoing parathyroidectomy at a single tertiary care medical centre. METHODS Prospectively collected data from Janu...

INTRODUCTION Postoperative parathyroid hormone (PTH) levels as a predictor of hypocalcaemia in patients subjected to total thyroidectomy is analyzed. MATERIAL AND METHOD Prospective study involving 67 patients who underwent total thyroidectomy due to a benign disease. Serum PTH and ionised calcium were measured 20 h after surgery. Sensitivity, specificity and predictive values of PTH and ioni...

BACKGROUND This analysis was performed to further characterise treatment-emergent hypocalcaemia in patients with bone metastases receiving denosumab. METHODS Laboratory abnormalities and adverse events of hypocalcaemia in patients with metastatic bone disease were analysed using data from three identically designed phase 3 trials of subcutaneous denosumab 120 mg (n = 2841) versus intravenous ...