lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. it has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. to overcome the poor bioavailability of the drug, transdermal patches have been prepared. the present study also aims at optimization of ...

Background: Leptadenia hastata (L. Hastata) is a plant used for various diseases in Nigeria. This study evaluated the protective effects of L. hastate on the haematological and biochemical alterations in adrenaline-induced hypertensive rats. Methods: Twenty-five rats were divided equally into five groups (A-E). Groups A-D were given 0.5 mg/kg adrenaline, groups A and B were treated with 100 an...

1. In Dahl S rats becoming hypertensive while on a diet of high NaCl content there appears to be a blood-borne humoral agent which produces vasoconstriction in a bioassay using the isolated hindquarters of rats. 2. This vasoconstrictor effect strongly suggests the presence of a humoral pressor agent or the lack of a vasodilator agent in the blood of hypertensive S rats. 3. The vasoconstrictor e...

Hypertensive urgencies are common clinical occurrences in hypertensive patients. The definition of hypertensive urgencies (target blood pression) were not consistent, but involved often target end-organ damage in emergencies. Epidemiology and physiopathology are briefly described. Treatment practices of hypertensive crisis were difficult because of the lack of evidence supporting the use of one...

purpose : to investigate the association of primary open angle glaucoma (poag) and systemic hypertension in patients referred to farabi eye hospital methods : in this case-control study in farabi eye hospital. one hundred patients were selected randomly from poag patients of glaucoma clinic, farabi eye hospital. control group consists of 100 patients, candidates for cataract surgery. history of...

PURPOSE Intravenous antihypertensive agents for the treatment of hypertensive emergencies are reviewed. SUMMARY An estimated 500,000 people in the United States experience a hypertensive crisis annually. Hypertensive emergency is associated with significant morbidity in the form of end-organ damage. Rapid controlled reduction of blood pressure (BP) may be necessary to prevent or minimize end-...

BACKGROUND Hemorrhage volume is an important predictor of outcome in patients with intracerebral hemorrhage (ICH). It is not clear why in some patients ICH volume is larger than in others. Identification of modifiable factors responsible for large-volume hemorrhage in hypertensive patients may help to reduce ICH-related morbidity and mortality. OBJECTIVE The objective of this study was to ide...

how to cite this article: sharifian m. hypertensive encephalopathy. iran j child neurol 2012; 6(3):1-7. hypertension is called the silent killer and vital organs such as the brain, eyes,kidneys and the heart are the targets. seizure, central nervous system (cns)hemorrhage, and cerebrovascular accident (cva), blindness and heart attacksare the end points.the prevalence of hypertension in childre...

to evaluate the value of random urinary protein creatinine ratio in prediction of 24h proteinuria in hypertensive pregnancies. method: random urine samples and routine 24h urine collections were collected from hypertensive pregnant women (n=100). reliability of random urinary protein-creatinine ratio was assessed by receiver operator characteristic (roc) curve to detect significant proteinuria ...