the previous large retrospective studies demonstrated that treatment with statins reduces both the incidence of prostate cancer by 50% and serum prostate specific antigen (psa) level up to 40%. however the main problem in those studies was the absence of control groups of men with hypercholesterolemia without statin treatment. we performed a small prospective controlled clinical trial to assess...

OBJECTIVE Experimental studies suggest that maternal hypercholesterolemia may be relevant for the early onset of cardiovascular disease in offspring. We investigated the effect of perinatal hypercholesterolemia on the atherosclerosis development in the offspring of apolipoprotein E-deficient mice and the underlying mechanism. APPROACH AND RESULTS Atherosclerosis and related parameters were st...

Objective(s): We examined the effects of endurance exercise in the presence of Bunium persicum extract administration on lipid profile and cardiorespiratory capacity in hypercholesterolemic male mice. Materials and Methods: Forty male hypercholesterolemic mice were divided into four groups: Vehicle, Endurance exercise (EE), Bunium persicum extract (BPE), and EE + BPE. The exercise protocol was ...

objective(s): we examined the effects of endurance exercise in the presence of bunium persicum extract administration on lipid profile and cardiorespiratory capacity in hypercholesterolemic male mice. materials and methods: forty male hypercholesterolemic mice were divided into four groups: vehicle, endurance exercise (ee), bunium persicum extract (bpe), and ee + bpe. the exercise protocol was ...

Our lab has shown that left circumflex coronary artery (LCX) perivascular adipose tissue (PAT) blunts endothelin-1 (ET-1)-induced maximal contractions in normal pigs on low- and high-fat diets. Other studies report that PAT exerts anticontractile effects on agonist-induced arterial contraction via release of a relaxing factor that acts on the underlying vasculature. The purpose of this study wa...

Fish arsik soup is a popular traditional food in North Sumatera especially Batak ethnic. This research aimed to evaluate the effects of different dose mackerel fish on body weight and LDL blood level rats that were given cholesterol rich feed namely quail egg yolk. Research was performed by using Randomized Group Design. Forty male grouped into 5 groups. The first group (K1) negative control wh...

The diameter, blood velocity, and blood flow of the brachial artery were evaluated with a pulsed-Doppler apparatus before and after wrist occlusion in 16 normocholesterolemic and 27 hypercholesterolemic male subjects of similar age and body mass index. Before occlusion, no hemodynamic differences were observed between the two groups. Occlusion significantly reduced blood velocity and blood flow...