losartan potassium is a well known orally active non-peptide angiotensin ii receptor antagonist. losartan potassium and its principle active metabolites block the vasoconstrictor and aldosterone secreting effect of angiotensin ii by selectively blocking the binding of angiotensin ii to at1 receptors. the drug is reported to promote the decrease in ventricular hypertrophy, salt and water excreti...

Fast dissolving drug delivery is the new approach to administer drugs; mouth dissolving film is one of them. The object of the present research work was to formulate a mouth dissolving film of Zolpidem tartrate from polymers Hydroxypropyl cellulose (EF-P) with a combination of Hydroxypropyl methyl cellulose K-15 by solvent casting method for enhancing the drug release rate and absorption to inc...

The relaxation processes in cellulose, methyl cellulose, hydroxypropyl cellulose, and hydroxypropylmethyl cellulose were studied by dielectric spectroscopy. The dielectric spectra for these polysaccharides were measured in the frequency range from 100 Hz to 1 MHz and in the temperature range from 100 to 450 K. The dielectric relaxation data for cellulose, methyl cellulose, hydroxypropylmethyl c...

Edible films were made from proteins (corn-zein and wheat gluten) and celluloses (methyl cellulose and hydroxypropyl cellulose), and tested fog permeability of gases. Oxygen and carbon dioxide permeabilities of edible films were generally lower than those of plastic films. However, water vapor permeabilities of edible films were higher than those of plastic films. The concentration of plasticiz...

An earlier safety assessment of several cellulose polymers has been expanded to include cellulose itself and other cellulose polymers used in cosmetics. In general, these ingredients are modified cellulose polymers formed by reaction with the free hydroxyl groups in cellulose. The number of hydroxyl groups reacting, as well as the nature of the substitute group, largely determine the physical p...

Mucoadhesive microbeads of low methoxyl pectin were prepared, either alone or in combinations with hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, methyl cellulose and carbopol 934P, by ionotropic gelation. The influence of copolymers on mucoadhesivity, microbeads characteristics and in vitro drug release was investigated. Spherical microbeads with 78.69±0.59 to 85.84±0.78% drug...

The current study deals with the synthesis of novel hydroxypropyl methyl cellulose acrylate (HPMCAA) by the process of esterification of hydroxypropyl methyl cellulose and acryloyl chloride. The polymers were characterized by FTIR spectrophotometry, DSC, XRD and haemocompatibility studies. The microstructures of the HPMC and HPMCAA powders were studied under a scanning electron microscope. The ...

The aim of this work was to investigate the effects of the nature and concentration of cellulose derivatives on the release kinetics of ibuprofen from hydrogel matrices using a response surface method (RSM). A series of cellulose derivatives, as methyl, hydroxyethyl, hydroxypropyl and hydroxypropyl methyl celluloses (MC, HEC, HPC and HPMC) were used as polymer platforms and their impacts on dru...

ABSTRACT
 In 2020 the number of cases Dengue Hemorrhagic Fever in Indonesia until 49th week reached 95,893 and caused death around 661 people. This study aims to obtain bestformula buccal film by optimizing concentration HPMC K15M Na. CMC evaluation characterization ofpreparations with 3 variations ratios against formulas on Na polymer excipients. include F1 0.67% : 0.33% ; F2 0.65% 0.5% F...