BACKGROUND Injection of calcium hydroxylapatite filler may result in nodule formation owing to superficial placement of the filler. Calcium hydroxylapatite nodules are difficult to reverse. Previously reported therapeutic options are limited and include intralesional triamcinolone, massage, needling, and excision, each with inconsistent results or potential for scarring. OBSERVATION We have o...

OBJECTIVES/HYPOTHESIS To evaluate the short-term voice outcomes of vocal fold augmentation using fat compared to calcium hydroxylapatite product Radiesse Voice (Merz Aesthetics). STUDY DESIGN Retrospective study design. METHODS Sixty-six consecutive patients with vocal fold insufficiency were recruited, including the final 33 patients treated with fat and all 33 patients treated with calciu...

OBJECTIVE To evaluate the efficacy of injectable calcium hydroxylapatite for treatment of velopalatal (VP) insufficiency (VPI). DESIGN Observational case series of 7 patients treated with injectable calcium hydroxylapatite for VPI and followed for 10 to 24 months. SETTING Academic pediatric otolaryngology practice. PATIENTS Seven children aged 6 to 16 years with clinically significant VPI...

OBJECTIVES/HYPOTHESIS To evaluate the potential for injectable, permanent bone augmentation by assessing the biocompatability and bioactivity of subperiosteal hydroxylapatite (Radiesse) deposition in a rat model. STUDY DESIGN Randomized controlled animal model. METHODS Fourteen adult Sprague Dawley rats were injected in the parietal skull with 0.2 ml of hydroxylapatite (10 animals) or 0.2 m...

INTRODUCTION: Voice disorders resulting from glottic insufficiency create a significant burden for patients1. Treatment options have ranged from voice therapy to invasive laryngeal surgery. Over the past century, however, vocal fold injection augmentation has come forward as a safe and efficacious means to treat unilateral vocal cord paralysis, paresis, and atrophy2. Through extensive investiga...

OBJECTIVES This study sought to determine the efficacy and safety profile of calcium hydroxylapatite filler in the treatment of acne scars. METHODS Ten subjects with a variety of acne scars were treated with calcium hydroxylapatite filler. RESULTS Saucerized acne scars responded to treatment; ice-pick scars did not. Results lasted, at least to some degree, for 12 months after treatment. No ...

BACKGROUND The substitution of Ca(2+) in Ca-hydroxylapatite by toxic Cd(2+) can cause the forming of Cd-hydroxylapatite and is a significant issue in a great variety of research areas, which hence needs an understanding of the essential physicochemical characteristics. Unfortunately, the solubility product and thermodynamic data for Cd-hydroxylapatite in water under a variety of conditions now ...

Formation of hydroxylapatite through the precipitation and evolution of calcium phosphate precursor phases under varying conditions of temperature (25–90 °C), pH (6.5–9.0), and calcium to phosphorus ratio (1.0, 1.33, 1.5, and 1.67) comparable to those found in many sediments and soils were studied. The products of low-temperature precipitation were analyzed by ex situ X-ray diffraction and SEM,...

We describe a patient who experienced diffuse, treatment-refractory facial inflammatory reaction following the injection of calcium hydroxylapatite with lidocaine. The was attributed to undiagnosed Hashimoto's thyroiditis. Exogenous thyroid hormone replacement therapy rapidly resolved inflammation associated this type autoimmune hypothyroidism.