background spinal anesthesia is an important and commonly used method for surgical anesthetic in operating rooms. however, even with identical drug dosage and administration mode, the extent of drug distribution in vivo is highly variable and difficult to control. preanesthetic administration of fluids immediately before spinal anesthesia (preload) is normal practice. the choice of fluid type m...

INTRODUCTION This study compared the effects of hydroxyethyl starch 130/0.4, hydroxyethyl starch 200/0.5, and succinylated gelatin on oxidative stress and the inflammatory response in a rodent hemorrhagic shock model. METHODS Sodium pentobarbital-anesthetized adult male Wistar rats (200 g to 220 g) were subjected to a severe volume-controlled hemorrhage using arterial blood withdrawal (30 mL/...

Hydroxyethyl starches (HES) are commonly used synthetic colloidal solution in veterinary medicine. Despite of possible adverse effect to kidney injury in human, there is no report about nephrotoxic effects of HES in dogs. HES was administered to a Golden retriever (4-year-old, intact male) with ascites in order to increase plasma osmolality. Initially, the dog was mild azotemic, however, kidney...

BACKGROUND Hydroxyethyl starches (HES) accumulate in the circulation when administered repeatedly. Accumulation is thought to be partly responsible for undesirable effects (tissue storage, blood coagulation impairment, and itching). HES 130/0.42 with low molecular weight and a low level of substitution has recently been developed in order to reduce those risks. METHODS In healthy volunteers, ...

Introduction Previous research has indicated that fluid choice is an important component of the resuscitation of the critically-ill patient. Synthetic hydroxyethyl starches (HES) may remain within the intravascular space compared to crystalloid solutions, yet they have also been associated with acute kidney injury. Data comparing HES and crystalloid solutions in anesthesia is incomplete. The go...

Epidural injection of hydroxyethyl starch may be a suitable alternative for treatment of post-dural puncture headache (PDPH) if epidural blood patch is contraindicated. We reported eight consecutive female patients with accidental dural puncture (ADP), among whom prophylactic or therapeutic epidural injection of hydroxyethyl starch was performed. Prophylactic epidural injection of hydroxyethyl ...

OBJECTIVES To evaluate the effect of the intraoperative use of hydroxyethyl starch on the need for blood products in the perioperative period of oncologic surgery. The secondary end-points included the need for other blood products, the clotting profile, the intensive care unit mortality and length of stay. METHODS Retrospective observational analysis in a tertiary oncologic ICU in Brazil inc...

abstract posttraumatic intravasation of fat and debris can lead to a cascade of events. hydroxyethyl starches (hes) markedly suppress neutrophil influx by decreasing pulmonary capillary permeability and facilitating tissue oxygenation by improving microcirculation. it was hypothesized that in hypoxemic femur injury patients undergoing operative stabilization, hes administration will prevent the...

BACKGROUND Patients with sepsis typically require large resuscitation volumes, but the optimal type of fluid remains unclear. The aim of this systematic review was to evaluate current evidence on the effectiveness and safety of hydroxyethyl starch for fluid management in sepsis. METHODS Computer searches of MEDLINE, EMBASE and the Cochrane Library were performed using search terms that includ...

a 40-year-old male patient with suicidal ingestion of one tablet of aluminium phosphide was referred to the department of toxicology emergency of baharloo hospital, tehran, iran. the garlic odor was smelled from the patient and abdominal pain and continuous vomiting as well as agitation and heartburn were the first signs and symptoms. systolic and diastolic blood pressures at the arrival time w...