Naturally occurring hydroxamic acids and hydroxamates are reviewed and classified according to the chemistry of the hydroxamic acid functions. The identity of the Fe(m) trihydroxamate albomycin ö2 with antibiotic Ro 5-2667 is established. TABLE OF CONTENTS 1. Monohydroxamic acids 1.1. Linear hydroxamic acids 1.1.1. Primary hydroxamic acids 1.1.2. Secondary hydroxamic acids 1.2. Cyclic hydroxami...

Hydroxamic acids have been reported to be potent and specific inhibitors of urease (EC 3.5.1.5) activity of plant and bacterial origin. The present investigation was performed on the inhibitory effect of hydroxamic acid derivatives of naturally occurring amino acids on the urease activity of the Jack Bean and the alimentary tracts of rats. Methionine-hydroxamic acid was the most powerful inhi...

Roots of young seedleings of barnyard grass, maize, rye and wheat secret hydroxamic acids. Their compexes with Fe/III/-ions are available sources of iron. It is possible that the cyclic hydroxamic acids play a role in the alternative mechanism of iron uptake. The hydroxamic acids secreted by barnayard grass roots have an allelopathic role by inhibiting the roots growth of rice. Acta Biol Szeged...

Hydroxamic acids find many applications in chemistry and biology and have been the subject of many experimental investigations. Theoretical studies are not as frequent. However, the smallest homolog, formohydroxamic acid (FHA), has been studied at various levels, including high-level ab initio and density functional with large basis sets. All studies indicate that it exists as the Z-amide tauto...

A new method for synthesis of amides and hydroxamic acids from nitroarenes and aldehydes is described. The MnO2 catalyzed thermal deoxygenation of nitrobenzene resulted in formation of a reactive nitroso intermediate which on reaction with aldehydes provided amides and hydroxamic acids. The thermal neat reaction in the presence of 0.01 mmol KOH predominantly led to formation of hydroxamic acid ...

We describe a novel two-step approach for the synthesis of compounds with hydroxyl-amide group (hydroxamic acids), which are widely known their biological activity (histone deacetylase inhibitors, matrix metalloproteinases inhibitors and others). The first stage is N-substituted succinimide via reaction aromatic amine or carboxylic acid hydrazide succinic anhydride. second step involves imide r...

OF ORGANOGERMANIUM AND ORGANOTIN DERIVATIVES OF HYDROXAMIC ACIDS Valery S. Petrosyan*, Natalia S. Yashina, and Sergei V. Ponomarev Department of Chemistry, M. V. Lomonosov University, Moscow 119899, Russia Hydroxamic acids as the precursors oftheir organogermanium and organotin derivatives have been themselves intensively studied fi’om the viewpoint of their potential biological activities [1-3...

calix(6)arene hydroxamic acids (iii) are synthesised for the first time by reactingcalix(6)arene acid chloride(ii) with substituted hydroxylamines at low temperature in the presence ofsodium bicarbonate. the p-carboxycalix(6)arene(i) is obtained by an acid catalysed condensationreaction of p-hydroxybenzoic acid and formaldehyde. these calixarenes are characterised by meltingpoint, uv, ir, 1h nm...

Hydroxamic acids demonstrated mutagenic and antibacterial activities. These activities appear to be dependent on the hydroxamic acid function and are probably due to the interaction with deoxyribonucleic acid.

Hydroxamic acids serve as a monsulfhydril bisubstrate analog inhibition of fernesyl protein transferase (FPT), the enzyme catalysing fernesylation of p21ras. Tumor necrosis factor (TFN) is specifically prevented by synthetic hydroxamic acid-based metalloproteinase inhibitors. Suberoyanilide hydroxamic acid (SAHA) have been identified as histone deacetylase inhibitors based on their ability to i...