BACKGROUND The humbug gene is a truncated isoform of Aspartyl β-hydroxylase (ASPH) gene that is overexpressed in many human malignancies. In recent years, since humbug has received increasing attention, it is considered as a potential therapeutic molecular target. Therefore, it is necessary for preparing humbug protein and its monoclonal antibody to investigate its structure and function. MET...

Human aspartyl-(asparaginyl)-β-hydroxylase (HAAH) is a type 2 transmembrane protein and an α-ketoglutarate-dependent dioxygenase that can stereospecifically catalyze the post-translational hydroxylation reaction of β-carbon atoms of aspartic acid and asparagine residues present in epidermal growth factor-like domains of certain specific proteins. Humbug is a truncated isoform of aspartyl (aspar...

background: the humbug gene is a truncated isoform of aspartyl β-hydroxylase (asph) gene that is overexpressed in many human malignancies. in recent years, since humbug has received increasing attention, it is considered as a potential therapeutic molecular target. therefore, it is necessary for preparing humbug protein and its monoclonal antibody to investigate its structure and function. meth...

Two human gastric cancer cell lines of differing invasive potential, SNU-484 and SNU-638 cells, were examined using subtractive suppression hybridization in a search for any genes associated with metastasis. Of the eight cDNAs identified as being differentially expressed genes, it was determined that humbug, which encodes a truncated isoform of aspartyl (asparaginyl) beta-hydroxylase (AAH) miss...

Populations of reef fish are widely believed to be limited by availability of larval recruits, not by density dependent processes operating during and after settlement of young stages in the reef environment. Our research explores and challenges this thinking. We are utilizing field observations and experiments to determine what factors affect spatial distribution, abundance, and population dyn...

Clemens Martin Auer gilt als einer der einflussreichsten Strippenzieher des österreichischen Gesundheitssystems. Er begründet im Interview, warum eine Beschneidung Wahlarztsystems doch Sinn mache und wieso er die Kassenreform für Humbug hält.