tissue nutrient supply may be synchronized with endogenous physiological rhythms to optimize animal and human health. glucose tolerance and insulin sensitivity have endogenous rhythms that are not essentially dependent on food type and eating. human glucose tolerance declines as day comes into night. based on such evolutionary findings, large evening meals must be avoided to reduce risks of vis...

by late 18th or early 19th century, albino rats became the most commonly used experimental animals in numerous biomedical researches, as they have been recognized as the preeminent model mammalian system. but, the precise correlation between age of laboratory rats and human is still a subject of debate. a number of studies have tried to detect these correlations in various ways. but, have not s...