Background: Cancer is the priority of the World Health Organization (WHO) and a serious challenge in death of human untimely. Assessment of social and physiological risk factors in gastric carcinoma patients can reveal the reasons of high prevalence gastric carcinoma in Sanandaj city. Methods: In a descriptive cross-sectional study, the variables of sex, age, education, occupation and active H...

Objective(s): In the present study,a new series of 6-methoxy-2-arylquinoline analogues was designed and synthesized as P-glycoprotein (P-gp) inhibitors using quinine and flavones as the lead compounds. Materials and Methods: The cytotoxic activity of the synthesized compounds was evaluated against two human cancer cell lines including EPG85-257RDB, multidrug-resistant gastric carcinoma cells (P...

Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) and flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). The flavonoids in licorice are known to have strong anti-cancer activities. Quercetin, the most abundant flavon...

BACKGROUND It is well known that the incidence of gastric carcinoma is lower in females than in males. Therefore, androgens have been proposed to play an important role in modifying the development of gastric carcinoma. 5Alpha-reductase (5alpha-reductase) types 1 and 2 and 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD type 5) are considered important local regulators of androgen produc...

objective(s): expression of her2 in gastric carcinoma has direct prognostic and therapeutic implications in patient management. the aim of this study is to determine whether a relationship exists between standardized uptake value (suv) and expression of her2 in advanced gastric carcinoma. methods: we analyzed the 18f-fdg pet/ct results of 109 patients that underwent gastrectomy for advanced gas...

This study reports the electrophoretic pattern of the proteins in human gastric juice of control patients and patients with gastric ulcer and gastric carcinoma. Autodigestion was prevented by intragastric neutralization. The statistical limits of normal are defined and the changes found in the gastric juice of gastric ulcer and gastric patients with gastric carcinoma described.

background the process of neoplastic transformation in the stomach has been reported to be associated with decreased expression of normal mucins of the gastric mucosa and denovo expression of mucins that are normally expressed in other organs. this association may be used as a means to bring new insights into biologic behavior and genetic pathways in the development of gastric cancer. there are...

cancer starts with a change in one single cell. this change may be initiated by external agents and genetic factors. cancer is a leading cause of death worldwide and accounts for 7.6 million deaths (around 13% of all deaths) in 2008. lung, stomach, liver, colon and breast cancer cause the most cancer deaths each year. in this review, different aspects of gastric cancer; including clinical, path...

BACKGROUND Gastric cancer is one of the most common and lethal malignant cancers worldwide, and numerous epidemiological studies have demonstrated that Helicobacter pylori (H. pylori) infection plays a key role in the development of gastric carcinomas. Our previous studies showed that aquaporin 3 (AQP3) is overexpressed in gastric carcinoma and promotes the migration and proliferation of human ...

The expression of interleukin 8 (IL-8) by human gastric carcinomas directly correlates with tumor vascularity and disease progression. To determine whether IL-8 can act in an autocrine manner to regulate the expression of other disease-progression genes, we examined the expression of IL-8 receptors IL-8RA (CXCR1) and IL-8RB (CXCR2) in six different human gastric carcinoma cell lines and 38 surg...