Background: Calprotectin is cytotoxic agent that its anti-tumor effects are governed through suppression of topoisomerase II a key enzyme in apoptosis. In previous studies, cytotoxicity and apoptotic effects of calprotectin are shown on different cancer cell lines, but not human gastric cancer cell lines. In the present study, cytotoxicity and apoptotic effects of calprotectin on human gastric ...

abstract background: chemotherapy by using agents such as etoposide is a common way for inhibition of tumors. this treatment is accompanied by many undesirable side effects. calprotectin is an abundant protein in the neutrophil cytosol, it has growth-inhibitory and apoptosis-inducing activities against various cell types such as tumor cells. in this study to introduce calprotectin as a suitable...

introduction: human calprotectin is an abundant protein in the neutrophil, monocyte and macrophage cytosol. effect of proliferation inhibition of this protein has been elucidated on hepatoma, melanoma, murine fibrosarcoma lukemia and human adenocarcenoma breast cancer but not in human gastric cancer cell lines. in present study, in vitro proliferation inhibition effect of calprotectin in differ...

Calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. It has been reported that this protein has an apoptotic activity in tumor cells. Since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on HT29/219 and SW742 colon carcinoma and adenocarcinoma cell li...

background: calprotectin is cytotoxic agent that its anti-tumor effects are governed through suppression of topoisomerase ii a key enzyme in apoptosis. in previous studies, cytotoxicity and apoptotic effects of calprotectin are shown on different cancer cell lines, but not human gastric cancer cell lines. in the present study, cytotoxicity and apoptotic effects of calprotectin on human gastric ...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 one of the prominent types of connective tissue cells is fibroblast that synthesizes and maintains the extracellular matrix of many animal tissues. previous studies illustrated that calprotectin protein has different cytotoxicity effects on fibroblast cells. calprotectin is abundant in the neutrophil cytosol; it has growth...

aim : in this paper effect of combinational usage of calprotectin and etoposide on ags cell line is studied. background : application of combined toxic agents such as etoposide and cicplatin are commonly used for chemotherapy purposes. as a matter of fact, calprotectin and etoposide were both applied on human gastric adenocarcinoma cell line (ags) as antitumor agents. both calprotectin and etop...

Calprotectin, a heterodimeric complex belonging to the S100 protein family, has been found predominantly in the cytosolic fraction of neutrophils. In the present study, human calprotectin was purified from neutrophils using two-step ion exchange chromatography. The purified protein was used for circular dichroism study and fluorescence analysis in the presence of calcium and zinc at physiologic...

calprotectin, a calcium-bound protein complex, is abundant in the cytosol of neutrophils. it has been reported that this protein has an apoptotic activity in tumor cells. since calprotectin increases in colorectal cancer, this study was conducted to investigate, for the first time, the cytotoxicity/apoptotic effect of calprotectin on ht29/219 and sw742 colon carcinoma and adenocarcinoma cell li...