currently cancer is considered as one of the main factors of mortality globally. many chemicals in our environment can cause genetic mutations and are potentially responsible for millions of cancer-related deaths. nowadays the scientists are looking for food materials which can potenthially prevent the cancer occurrence. the purpose of this research is to examine antimutagenicity and anticancer...

Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining. Negative Tbx2 staining was observed in normal astrocytes, and positive nuclea...

Cells tend to soften during cancer progression, suggesting that mechanical phenotyping could be used as a diagnostic or prognostic method. Here we investigate the cell mechanics of gliomas, brain tumors originate from glial cells progenitors. Using two microrheology techniques, single-cell parallel plates rheometer probe whole-cell and optical tweezers intracellular rheology, show discriminates...

Malignant astrocytomas are the most common and lethal adult primary brain tumor. Retroviral gene trapping of nontransformed neonatal astrocytes from a glial fibrillary acidic protein (GFAP):(V12)Ha-Ras murine astrocytoma model led to isolation of the transcription factor Gata6. Loss of Gata6 resulted in enhanced proliferation and transformation of astrocytes. Human malignant astrocytoma cell li...

Abstract Introduction Acquisition of somatic mutations is essential for the development malignant tumors such as diffuse gliomas. Recent single-cell analyses have pointed out importance mosaicism in pathogenesis cancer. Here we report a case IDH (isocitrate dehydrogenase)-mutant astrocytoma that has relapsed after intensive chemoradiation with IDH1 R132H mutation. Clinical and Pathological Find...

The PIM1 protein is an important regulator of cell proliferation, the cell cycle, apoptosis, and metabolism in various human cancers. MicroRNAs (miRNAs) are powerful post-transcriptional gene regulators that function through translational repression or transcript destabilization. Therefore, we aimed to identify whether a close relationship exists between PIM1 and miRNAs. PIM1 protein levels and...

Glioblastoma multiforme is one of the most serious malignant brain tumors and is characterized by resistance to chemotherapy and radiation therapy. Recent studies suggest that autophagy may play an important role not only in the regulation of cancer development and progression but also in determining the response of cancer cells to anticancer therapy. The purpose of the present study was to ass...