background: oncolytic herpes simplex virus (ohsv) vectors lacking γ34.5 has demonstrated anticancer effects without affecting normal cells. therefore, they are considered as ideal templates to construct efficient vectors for tumor targeting and cancer gene therapy. herein, we reported construction of three single/dually-labeled recombinant hsv-1 vectors, which provide an opportunity to replace ...

Background: The involvement of sweat glands in preventing dry skin mice has been suggested. We previously demonstrated that inoculating the thigh wild-type immunocompetent C57BL/6J (B6) with cutaneous herpes simplex virus-1 (HSV-1) led to infection glands, which turn caused sweating disturbance followed by development skin. Interestingly, HSV-1–inoculated recovered from showed neither HSV-1–ind...

herpes simplex virus (hsv) is one of the common pathogenic viruses of humans bing. this study aimed to determin anti-herpes virus activity of mentha piperita extracts in vitro. mentha piperita extracts can inhibit hsv infection when the cells treated before viral adsorbtion. hsv-1 were also inhibited by menthol after viral adsorption. hsv-1 viral particles were directly inhibited and viral yiel...

Background: Oncolytic herpes simplex virus (oHSV)-based vectors lacking γ34.5 gene, are considered as ideal templates to construct efficient vectors for (targeted) cancer gene therapy. Herein, we reported the construction of three single/dually-flourescence labeled and γ34.5-deleted, recombinant HSV-1 vectors for rapid generation and easy selection/isolation of different HSV-Based v...

Herpes simplex virus type 1 (HSV-1) with a worldwide distribution has been reported in all human populations, resulting in a clinical spectrum of infections. Although HSV type 2 (HSV-2) is known as the most common cause of genital herpes, an increasing number of cases with genital herpes are caused by HSV-1. The present study aimed to discuss the changes in the epidemiology of HSV-1 infection i...

Objective(s): Oncolytic Herpes simplex virus type 1 (HSV-1) has emerged as a promising strategy for cancer therapy. However, development of novel oncolytic mutants has remained a major challenge owing to low efficiency of conventional genome editing methods. Recently, CRISPR-Cas9 has revolutionized genome editing.Materials and Methods: I...

Emergence of drug resistance and adverse effects often affect the efficacy nucleoside analogues in therapy Herpes simplex type 1 (HSV-1) 2 (HSV-2) infections. Host-targeting antivirals could therefore be considered as an alternative or complementary strategy management HSV To contribute to this advancement, here we report on ability a new generation inhibitor key cellular enzyme de novo pyrimid...

Background Researching people with herpes simplex virus (HSV) is challenging because of poor data quality, low user engagement, and concerns around stigma anonymity. Objective This project aimed to improve collection for a real-world HSV registry by identifying predictors infection selecting limited number relevant questions ask new users determine their level risk. Methods The US National Heal...