The introduction and evolution of hematopoietic stem cell transplantation (HSCT) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. Today, HSCT is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...

Background: Sickle cell anemia (SCA) is an inherited monogenic disorder. The clinical symptoms of SCA are protean, including vaso-occlusion, hemolysis, early stroke, leg ulcers, multi-organ failure, and increased risk of premature death. Hematopoietic stem cell transplantation is the only treatment identified to reduce SCA-related organ damage. Unfortunately, graft rejection is a significant im...

Hematopoietic stem cell transplantation (HSCT) has been practiced for more than 30 years. Hematological malignanciesare the main indications for this treatment. However, its indications in adults are different from children.Advances in chemotherapy and target therapy have improved treatment outcome of some of the very high riskcancers, and changed indications of HSCT in children. Multi-center c...

introduction: this review reports the current results of hematopoietic stem cell transplantation (hsct) in patients who had received transplantation in the hematology-oncology and sct research center, tehran, iran. methods: in iran, from 1991 through 2010, a total of 3170 hematopoietic stem cell transplantation have been carried out. the male/female patient ratio was 1909/1261 with a median age...

BACKGROUND Optimal post-remission strategy for patients with acute myeloid leukemia (AML) is matter of intense debate. Recent reports have shown stronger anti-leukemic activity but similar survival for allogeneic stem cell transplantation (allo-HSCT) from matched sibling donor compared to autologous transplantation (auto-HSCT); however, there is scarcity of literature confronting auto-HSCT with...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Systemic sclerosis (SSc) is an autoimmune disorder that causes fibrosis in the skin and internal organs, including heart. Patients with SSc can have right ventricular (RV) systolic dysfunction absence pulmonary hypertension. Studies shown a predilection for impairment mid apical segments RV free wall compared to contr...

Hematopoietic stem cell transplantation (HSCT) is occasionally associated with cardiac dysfunction during long-term follow-up. Global longitudinal strain (GLS) has emerged as an early predictor of cardiotoxicity cancer therapy; however, the serial changes in GLS before and after HSCT have not been elucidated. To clarify association between GLS, we investigated HSCT. We evaluated function 1, 3, ...

Hematopoietic stem cell transplantation (HSCT) is widely used to treat hematological malignancies and nonmalignant disorders. Many advances have been made in improving the success of bone marrow transplantation. However, lack available matched related or sibling donors has posed a significant challenges availability proper utilization hematopoietic patients with malignancies. The rising alterna...

The article comments on the inherent difficulties of complex post-HSCT revaccination program and expected with COVID-19 vaccination HSCT recipients in troubled pandemic scenario.

Relevance: Kidney functions in treating acute myeloblastic leukemia (AML) undergo serious effects, especially elderly patients. Chemotherapeutic drugs used to prepare for hematopoietic stem cell transplantation (HSCT) inevitably affect patients’ kidney function. Moreover, involutive changes the kidneys can physiologically decrease function.
 The study aimed evaluate function an patient wit...