conclusions cervical cancer screening, comprising of both pap test and hpv testing, is an essential part of the routine health care for women as it can facilitate the detection of abnormal cervical cells. hpv infection can produce abnormal pap test results; also, certain types of hpv are associated with cancer. therefore, it is important to diagnose abnormal cervical tissues before the developm...

results human papillomavirus was found in 62.1% of the samples obtained from the patients. among the hr and lr types, hpv-6 was the major genotype 64.8%. type 16 and 18 were the most frequent hr-hpv types (presented in 26% of the patient), followed by type 50s (24.7%), 45, 30s, and 11 (1.8% from each). multiple hpv infections were presented in 40.7% of the positive genotyping specimens. backgro...

The results of HPV detection in 550 cervical samples by cervical cytology were compared with the sequencing analysis and HPV genotyping 9G membrane test. The HPV genotyping 9G membrane test can efficiently identify and discriminate five HR-HPV genotypes. The 100% identical results of HPV genotyping 9G membrane tests with the sequencing results in 550 clinical samples ensure its wide clinical ap...

The need for accurate genotyping of human papillomavirus (HPV) infections is becoming increasingly important, since (i) the oncogenic potential among the high-risk HPV genotypes varies in the pathogenesis of cervical cancer, (ii) monitoring multivalent HPV vaccines is essential to investigate the efficiency of the vaccines, and (iii) genotyping is crucial in epidemiologic studies evaluating HPV...

Cervical cancer is the fourth most common cancer in women worldwide, and the human papillomavirus (HPV) is the main causative agent for its development. HPV is a heterogeneous virus, and a persistent infection with a high-risk HPV contributes to the development of cancer. In recent decades, great advances have been made in understanding the molecular biology of HPV, and HPV's significance in ce...

background: the accuracy of diagnostic assays in human papillomavirus (hpv) genital infection and cervical cancer has remained a clinical challenge in diagnosis.  evidence indicates that a large proportion of cervical cancer can be prevented through organized care for hpv and testing. countries with low per capita income, such as iran and its neighbours, have no national organized program for c...

In situ hybridization (ISH) was performed on paraffin-embedded tissues to detect multiple high-risk human papillomavirus (HPV) subtypes in 27 cases of cervical adenocarcinoma in situ (AIS) and adenocarcinoma (CA) specimens. These results were compared with those of HPV detection by HPV-PCR genotyping and p16 immunohistochemistry in the same specimens. Of the 27 cases, 17 (63%) showed HPV-DNA by...

Background: The accuracy of diagnostic assays in Human Papillomavirus (HPV) genital infection and cervical cancer has remained a clinical challenge in diagnosis.  Evidence indicates that a large proportion of cervical cancer can be prevented through organized care for HPV and testing. Countries with low per capita income, such as Iran and its neighbour...

BACKGROUND Epidemiologic studies have classified 18 genotypes of the human papillomavirus (HPV) as (probably) high-risk (HR) based on their association with cervical cancer, i.e., HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, and 82. Given the fact that certain HR HPV types confer an increased risk of cervical (pre)cancer, type-specific identification might aid clinica...

The results of the genital human papillomavirus (HPV) detection in 439 cervical samples by cervical cytology were compared with sequencing analysis and a newly developed HPV genotyping 9G membrane test. The excellent sensitivity and specificity of the HPV genotyping 9G membrane test was assured by a signal to noise ratio of more than 300 and a target hybridization to non-target hybridization ra...