introduction: the important of comparing performance of hospitals using hospital indicators, has been made the necessary of utilizing of the application model inevitable. this study aimed to compare hospital performance key indicators simultaneity. methods: in this descriptive cross sectional and retrospective study, 31 hospitals of isfahan university of medical sciences were evaluated in 2007....

XPO1 (exportin 1) is the main nuclear export protein with over 200 different protein cargos. XPO1 is overexpressed in tumor cells and high levels are correlated with poor prognosis. Selective Inhibitor of Nuclear Export (SINE) compounds block nuclear export by inhibiting XPO1. The first SINE compound, selinexor, shows promising anti-cancer activity across hematological and solid tumors in Phase...

INTRODUCTION In intensive care, occupancy is a commonly used measure. There is inconsistency however in its measurement and optimal occupancy targets need to be defined. The objectives of this literature review were to explore how occupancy is measured, reported, and interpreted and investigate optimal occupancy levels for ICUs. METHOD A literature search was performed using the Medline, Emba...

OBJECTIVES The authors investigated whether models using time series methods can generate accurate short-term forecasts of emergency department (ED) bed occupancy, using traditional historical averages models as comparison. METHODS From July 2005 through June 2006, retrospective hourly ED bed occupancy values were collected from three tertiary care hospitals. Three models of ED bed occupancy ...

Main Outcome Measure: Dose-dependent effect of smoking on occupancy of 4 2* nAChRs, as measured with 2-FA and PET in nAChR-rich brain regions. Results: Smoking 0.13 (1 to 2 puffs) of a cigarette resulted in 50% occupancy of 4 2* nAChRs for 3.1 hours after smoking. Smoking a full cigarette (or more) resulted in more than 88% receptor occupancy and was accompanied by a reduction in cigarette crav...