the human mdr1 gene encodes for a p-glycoprotein (pgp), which acts as an efflux pump that transports a large variety of substrates from the inside of cells to the outside until protection against xenobiotics. the g2677t/a polymorphism in exon 21 is associated with pgp expression and function in humans. the present study was aimed to determine the frequencies of this polymorphism in a healthy po...

hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. today this technology has found its place in the array of pharmaceutical manufacturing operations. melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

Solid dispersion is molecular dispersion of drug in a polymer matrix which leads to improved solubility and hence better bioavailability. Solvent evaporation technique was employed to prepare films of different combinations of polymers, plasticizer, and a modal drug sulindac to narrow down on a few polymer-plasticizer-sulindac combinations. The sulindac-polymer-plasticizer combination that was ...

this research was conducted to study the effect of lime based flux with the composition of cao-20%caf2-8%feo on simultaneous removal of phosphorus and sulfur from hot metal. the effects of na2o and oxygen blowing were also studied. the experiments were performed using an induction furnace and hot metal produced in isfahan steel company in the temperature range 1350-1450 ºc. the results showed t...

The recycling of waste plastics that include plastics that contain chlorine, such as polyvinyl chloride, is difficult because the chlorine leads to the corrosion of equipment. Then, the dechlorination method of waste plastics containing chlorine (CCWP) that consists of a series of melt process and hot water process was examined. CCWP was put into the melt process with coal tar (HOB) and convert...

This research was conducted to study the effect of lime based Flux with the composition of CaO-20%CaF2-8%FeO on simultaneous removal of phosphorus and Sulfur from hot metal. The effects of Na2O and oxygen blowing were also studied. The experiments were performed using an induction furnace and hot metal produced in Isfahan Steel Company in the temperature range 1350-1450 ºC...

Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug ...

Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...