Objectives: Besides the well-known risk factors for atherosclerosis and cardiovascular disorders, hyperhomocystinemia is a recently defined factor that acts in pathogenesis of atherosclerotic diseases. It also plays role in development of end-stage renal disease. Homocysteine causes endothelial cell damage and proliferation in vascular smooth muscle cells. In this study, we aimed to document th...

BACKGROUND Hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (ESRD). Vitamin B12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients. METHODS Using all randomized controlled trials (RCTs), clinical trials and pre-post-trial studies ...

I read the article of Zhang, et al. with great interest. They investigated the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. The carotid-femoral pulse wave velocity (PWV) was significantly higher in the high homocyteine group than in the normal one, however, there was no differences in carotid-radial PWV between the high homocyteine group and th...

background: it is well documented that coronary artery bypass grafting (cabg) with cardiopulmonary bypass (cpb) causes ischemia and oxidative stress of the whole body. to compare the effect of on – pump and off –pump cabg on the induction of the oxidative stress and the metabolism of homocysteine which is involved in the synthesis of glutathione was investigated in the cabg patients during the ...

  Background :Hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (ESRD). Vitamin B12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients.   Methods : Using all randomized controlled trials (RCTs), clinical trials and pre-post-trial stu...

OBJECTIVE Folate depletion and hyperhomocysteinemia increase the risk for hepatic alcoholic damage and promote oxidative stress in animals. In addition, some investigators have reported an inverse association between serum folate and body mass index and a positive correlation between total homocysteine and fat mass. We investigated whether there is an association between serum folate and total ...

background :hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (esrd). vitamin b12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients.   methods : using all randomized controlled trials (rcts), clinical trials and pre-post-trial studi...

TO THE EDITOR: Jiang et al. (3) reported an important finding that vascular smooth cell migration was promoted by the resistin gene expression induced by ultrahigh concentrations of homocysteine (500 M). The homocysteine concentrations used by Jiang et al. were markedly higher than the physiological concentrations ( 100 M); therefore, the biological significance of the results of their study sh...