conclusions: anthropometric, biochemical, and ultrasonographic findings showed significant differences among pcos subgroups. the pcos subgroups with regular menstrual cycles (ha+pco), had high insulin resistance (ir) and gonadotropic hormonal abnormalities, compared with the im+ha+pco subgroups and controls. results: the pcos subgroups with regular menstrual cycles (ha+pco), had more luteinizin...

The glucose level linkages with breast cancer (BC) biomarkers are focused in the article adopting probabilistic modeling a real data set surveyed from 64 BC women and 52 normal along 10 interested study factors. It is derived that mean levels over for (P=0.02224) than normal. Mean inversely linked insulin (P< 0.00001), interaction effects of leptin adiponectin (leptin*adiponectin) (P=0.08834...

OBJECTIVE We sought to determine whether insulin resistance predicts the incidence and progression of coronary artery calcification (CAC). RESEARCH DESIGN AND METHODS We studied 5,464 participants not on hypoglycemic therapy from the Multi-Ethnic Study of Atherosclerosis (MESA). Each had baseline homeostasis model assessment of insulin resistance (HOMA-IR) and baseline and follow-up CAC score...

Although beta cell dysfunction has been proved to predict prognosis among humans and animals, its prediction on severity of disease remains unclear among children. The present study was aimed to examine the relationship between beta cell dysfunction and severity of disease among critically ill children.This prospective study included 1146 critically ill children, who were admitted to Pediatric ...

This study examined changes in insulin resistance (IR) in 120 youth over two years. IR was quantified via homeostatic model (HOMA-IR), and weight status changes were quantified via body mass index (BMI). When all participants were considered, the mean HOMA-IR and BMI increased 13.4% and 1.65 units, respectively. Change in BMI z-score and percent change in HOMA-IR were moderately associated (r =...

BACKGROUND Insulin resistance (IR) is associated with hepatic fibrosis and cirrhosis, regardless of its etiology but the mechanism of hyperinsulinemia in cirrhosis is still unclear. The current study was designed to assess hyperinsulinemia and pancreatic β-cell function in euglycemic cirrhosis of varied etiology. METHODS A cross sectional case control study of 100 subjects. IR was assessed by...

BACKGROUND Drugs with unspecific stimulating effects on beta-cell secretion increase the homeostasis model assessment (HOMA)-B score, indicating improved beta-cell "function." We investigated whether the beta-cell protection provided by adding pioglitazone (PIO) to glimepiride (GLIM) in comparison to up-titrating the GLIM dose alone is reflected by appropriate changes in several measures of bet...

We aimed to measure flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), and to evaluate the effects of waist circumference (WC), and body mass index Z (BMI-Z) score on these parameters in obese children. This case-control cross-sectional study included 70 obese and 40 non-obese children aged 7-14 years who presented with various complaints and had no concomitant diseases. FMD a...

Intestinal FGF19 has emerged as a novel endocrine regulator of hepatic bile salt and lipid metabolism. In patients with nonalcoholic fatty liver disease (NAFLD) hepatic lipid metabolism is deranged. A possible role of FGF19 in NAFLD has not been reported yet. In this study, we assessed intestinal FGF19 production and the hepatic response to FGF19 in NAFLD patients with and without insulin resis...

30 Intestinal FGF19 has emerged as a novel endocrine regulator of hepatic bile salt and lipid 31 metabolism. In patients with non-alcoholic fatty liver disease (NAFLD) hepatic lipid 32 metabolism is deranged. A possible role of FGF19 in NAFLD has not been reported yet. In this 33 study, we assessed intestinal FGF19 production and the hepatic response to FGF19 in NAFLD 34 patients with and witho...