Recent advances in sequencing technology have enabled the rapid generation of billions of bases at relatively low cost. A crucial first step in many sequencing applications is to map those reads to a reference genome. However, when the reference genome is large, finding accurate mappings poses a significant computational challenge due to the sheer amount of reads, and because many reads map to ...

This Essay reexamines Thomas Hobbes's understanding of international order. Hobbes defended the establishment of an all-powerful sovereign as the solution to interpersonal conflict, and he advanced an analogy between persons and states. Extending this "domestic analogy," theorists following Hobbes have supposed that a global sovereign would prove the solution to interstate conflict. Yet Hobbes ...

In the beginning of his essay on Thomas Hobbes in What is Political Philosophy, Leo Strauss asks the rather salient question of why we, as students of political philosophy in contemporary times, should read Hobbes?29 [1] The simplicity of this question, to say nothing of its relevance, cannot be overlooked. To study Hobbesian political philosophy is to say that it is relevant to us in some way;...

In this paper, I offer an alternative account of the relationship of Hobbesian geometry to natural philosophy by arguing that mixed mathematics provided Hobbes with a model for thinking about it. In mixed mathematics, one may borrow causal principles from one science and use them in another science without there being a deductive relationship between those two sciences. Natural philosophy for H...

of a paper for the Third International Conference on Computational Linguistics to be held in Sanga Sgby I 4 September 1969 .

Declaration: Hiermit erkläre ich, dass ich diese Arbeit selbständig verfasst habe, keine anderen als die angegebe-nen Hilfsmittel benutzt und alle Stellen, die dem Wortlaut oder Sinne nach anderen Werken ent-nommen sind, durch Angabe der Quellen als Entlehnungen kenntlich gemacht habe. Calvin: Ah! I got the letter I wrote to myself! Hobbes: What did you write? Calvin: " Dear Calvin, Hi! I'm wri...

So, where has touch been within social theory and spatial scholarship all this time? Where is it now and where might it be placed in the future? What kinds of knowledges are produced, validated and employed in researching the spaces of touch and the places of touching in different social contexts? These are the central concerns of Touching Space, Placing Touch. Before focussing on those distinc...

O propósito desse artigo consiste em discutir os termos da representação e teoria autorização Hobbes evidenciando, por sua vez, as adversidades incoerências no modo como a atribuição fictícia interfere na constituição autoridade Hobbes. Nesse sentido, torna-se necessário o pelo qual determina função do representante ausência de identificação autor, ou seja, sem qualquer condição atribuir aos se...

Leviathan In Metaphors we live by, Lakoff and Johnson cite Thomas Hobbes (1588-1679) and John Locke (1632-1704) as the chief proponents of a philosophical trend through which " the suspicion of poetry and rhetoric became dominant in Western thought " and " metaphor and other figurative devices [became] objects of scorn " (Lakoff and Johnson 1980: 190). In his overview over " Metaphor in the Phi...

In their classic analyses, Hobbes and Hume argue that offensively violating a covenant is irrational because the offense ruins one’s reputation. This paper explores conditions under which reputation alone can enforce covenants. The members of a community are modeled as interacting in a Covenant Game repeated over time. Folk theorems are presented that give conditions under which theHumean strat...