background: papillon-lefevre syndrome (pls) is a rare autosomal recessive disorder characterized by palmoplantar hyperkeratosis and early development of aggressive pe-riodontitis. although cathepsin c (ctsc) gene mutations have been established in about 70-80% of pls patients, it is assumed that the patients may have dysfunctioning of immune defense mechanisms. objective: to assess the associat...

previous studies have demonstrated some significant differences in hla allele frequencies in leukemic patients and normal subjects. we have analyzed hla class ii alleles and haplotypes in 60 iranian patients with acute myelogenous leukemia (aml) and 180 unrelated normal subjects. blood samples were collected after obtaining informed consents. from the patients and control dna extraction and hla...

Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population. Methods: Fifty pa...

background: a common human leukocyte antigen (hla) class ii allele, dqβ1*03:01, seems to be associated with bullous pemphigoid (bp) in caucasians whereas previous studies in other ethnic groups showed other hla class ii alleles as genetic predisposing factors for bp. objective: to investigate the association of hla class ii alleles and haplotypes with bp in iranian population. methods: fifty pa...

background: thalassemia is probably the most common single gene disorder causing a major public health problem in the world. currently, allogenic hematopoietic stem cell transplantation (hsct) is the only curative therapy for thalassemia. one major limitation of hsct is the lack of hla-identical sibling donors, so attention has turned to finding phenotypically matched unrelated donors. patients...

Background: Non-Hodgkin lymphoma (NHL) includes a wide range of diseases with different clinical and biological features. NHL is usually presented as localized or generalized lymphadenopathy. It has been suggested that the HLA class I and II are associated with susceptibility to NHL. Different ethnic groups have been found to have different HLA class I and II alleles which affect NHL. Objective...

Objective(s): The population in Iran is a genetic admixture of the ancestral Aryan and other populations neighboring Iran. Different ethnic groups in Iran show wide regional distributions for many human leukocyte antigen (HLA) alleles. Therefore, it is necessary and sensible to study the differences in HLA allele distribution in different area. We studied the HLA class I and II allele frequenci...

background: the study aimed to examine the association between human leukocyte antigen (hla) class ii allele frequencies and breast cancer in iranian women. methods: a total of 100 patients with pathologically proven breast cancer who referred to cancer institute were randomly selected and compared with a group of age matched healthy blood donors (n = 80). hla class ii alleles were determined b...

background: non-hodgkin lymphoma (nhl) includes a wide range of diseases with different clinical and biological features. nhl is usually presented as localized or generalized lymphadenopathy. it has been suggested that the hla class i and ii are associated with susceptibility to nhl. different ethnic groups have been found to have different hla class i and ii alleles which affect nhl. objective...