studies have shown that patients who do not produce donor specific and / or panel reactive anti-hla antibodies have a longer graft survival. the purpose of this study was to evaluate the posttransplant humoral immune response towards hla-class i antigens and the measurement of the serum creatinine levels which are used in monitoring posttransplant function of kidney. serum samples from 132 rena...

Background: Anti-HLA-antibodies are known to affect the allograft survival in transplant recipient patients. Objective: The aim of this study was to evaluate the association between anti-HLA antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (DBMI). Methods: Between June 2006 and May 2007, forty living unrelated donor kidney tra...

Background: Platelets can activate B cells and stimulate them for the production of antibodies. Since platelet microparticles (PMPs) originate from platelets, they may have the same virtue. In the present study, the effect of PMPs was investigated on the production of human leukocyte antigen (HLA)-specific antibody from B cells in vitro. Materials and Methods: In this experimental study, HLA-D...

Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and 3, leading to acantholysis. The etiology PV multifactorial, including genetic susceptibility. This retrospective study aimed evaluate association HLA class II alleles examine impact PV-associated on concentration anti-d...

Human Leukocyte Antigens (HLA) of fetus are responsible for induction of HLA antibodies in mother. Exposure to the mismatched paternal HLA antigens in the fetus gives rise to a polyclonal antibody response against paternal HLA antigens. HLA antibodies are present in the maternal circulation of the placenta and are absorbed onto the placenta [1]. The major source of HLA antisera is from sera of ...

background: anti-hla-antibodies are known to affect the allograft survival in transplant recipient patients. objective: the aim of this study was to evaluate the association between anti-hla antibodies and kidney allograft outcomes, particularly in recipients with concur-rent donor bone marrow cell infusion (dbmi). methods: between june 2006 and may 2007, forty living unrelated donor kidney tra...

studies on hla-g, a nonpolymorphic antigen of non-classical hla class i, is of basic and clinical significance. in the present study, the expression of hla-g proteins in the human skin tissue sections of normal and autoimmune pemphigus vulgaris (pv) individuals were investigated using monoclonal antibodies. the antibodies recognized both membrane-bound and soluble isoforms of hla-g. rt-pcr was ...

The regulation of immune mechanisms is controlled by major histocompatibility complex/human leukocyte antigen (MHC/HLA). Polymorphisms the HLA region have an impact on susceptibility to complex infectious and autoimmune diseases. present study was carried out determine frequencies ASMA, AMA, ANA, dsDNA, anti-LKM-1 auto-antibodies in hepatitis C patients their association with DRβ1 (*04) locus. ...