نتایج جستجو برای: hiwi2

تعداد نتایج: 8  

Journal: :Reports of biochemistry & molecular biology 2017
Zeeba Kamaliyan Sara Pouriamanesh Mona Amin-Beidokhti Amir Rezagholizadeh Reza Mirfakhraie

BACKGROUND The PIWI-interacting RNA (piRNA) pathway has an essential role in transposon silencing, meiosis progression, spermatogenesis, and germline maintenance. HIWI genes are critical for piRNA biogenesis and function. Therefore, polymorphisms in HIWI genes contribute to spermatogenesis defects and can be considered as risk factors for male infertility. The aim of the present study was to in...

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2014
Simon P. Keam Paul E. Young Alexandra L. McCorkindale Thurston H.Y. Dang Jennifer L. Clancy David T. Humphreys Thomas Preiss Gyorgy Hutvagner David I.K. Martin Jennifer E. Cropley Catherine M. Suter

The Piwi-piRNA pathway is active in animal germ cells where its functions are required for germ cell maintenance and gamete differentiation. Piwi proteins and piRNAs have been detected outside germline tissue in multiple phyla, but activity of the pathway in mammalian somatic cells has been little explored. In particular, Piwi expression has been observed in cancer cells, but nothing is known a...

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Journal: Reports of Biochemistry and Molecular Biology 2017
Amir Rezagholizadeh, Mona Amin-beidokhti, Reza Mirfakhraie, Sara Pouriamanesh, Zeeba Kamaliyan,

Background: The PIWI-interacting RNA (piRNA) pathway has an essential role in transposon silencing, meiosis progression, spermatogenesis, and germline maintenance. HIWI genes are critical for piRNA biogenesis and function. Therefore, polymorphisms in HIWI genes contribute to spermatogenesis defects and can be considered as risk factors for male infertility. The aim of the present study was to i...

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Journal: :reports of biochemistry and molecular biology 0
reza mirfakhraie tel: +98 21 22427903; fax: +98 21 23872572 zeeba kamaliyan department of medical genetics, school of medicine, shahid beheshti university of medical sciences, tehran, iran. sara pouriamanesh department of medical genetics, school of medicine, shahid beheshti university of medical sciences, tehran, iran. mona amin-beidokhti department of medical genetics, school of medicine, shahid beheshti university of medical sciences, tehran, iran. amir rezagholizadeh biology department, islamic azad university, east tehran branch, tehran, iran.

background: the piwi-interacting rna (pirna) pathway has an essential role in transposon silencing, meiosis progression, spermatogenesis, and germline maintenance. hiwi genes are critical for pirna biogenesis and function. therefore, polymorphisms in hiwi genes contribute to spermatogenesis defects and can be considered as risk factors for male infertility. the aim of the present study was to i...

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Journal: :Nucleic Acids Research 2014

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Journal: :Cellular & Molecular Biology Letters 2017

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Yuan Tian Dhirendra K Simanshu Jin-Biao Ma Dinshaw J Patel

Argonaute and Piwi proteins are key players in the RNA silencing pathway, with the former interacting with micro-RNAs (miRNAs) and siRNAs, whereas the latter targets piwi-interacting RNAs (piRNAs) that are 2'-O-methylated (2(')-OCH(3)) at their 3' ends. Germline-specific piRNAs and Piwi proteins play a critical role in genome defense against transposable elements, thereby protecting the genome ...

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Journal: :Nucleic Acids Research 2018

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