نتایج جستجو برای: histone deacetylase inhibitor

تعداد نتایج: 249468  

Journal: :iranian journal of pharmaceutical research 0
afshin zarghi department of medicinal chemistry, faculty of pharmacy, shahid beheshti university of medical sciences atefeh haji agha bozorgi department of medicinal chemistry, faculty of pharmacy, shahid beheshti university of medical sciences

histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. so design of new inhibitors is of great importance in pharmaceutical industries and labs. creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. this approach reduces the overall cost ass...

Journal: :jundishapur journal of natural pharmaceutical products 0
maryam moradi binabaj biochemistry and metabolic disorders research center, golestan university of medical sciences, gorgan, ir iran seyed ahmad hosseini nutrition and metabolic disease research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran alireza khoshbin khoshnazar biochemistry and metabolic disorders research center, golestan university of medical sciences, gorgan, ir iran jahanbakhsh asadi biochemistry and metabolic disorders research center, golestan university of medical sciences, gorgan, ir iran; biochemistry and metabolic disorders research center, golestan university of medical sciences, gorgan, ir iran. tel: +98-1732440225, fax: +98-1732421651

conclusions the increasing cell toxicity, apoptosis-inducing effects and decreasing telomerase activity may play an important role in the valproic acid and radiation mechanism. the current survey suggested that it is likely beneficial to combine valproic acid and gamma radiation to treat breast cancer. results combination of valproic acid and gamma radiation increased significantly cell toxicit...

Journal: :iranian red crescent medical journal 0
ladan akbarzadeh department of pharmacology, shahid beheshti university, tehran, ir iran; department of pharmacology, shahid beheshti university, tehran, ir iran. tel: +98-9121034458, fax: +98-2122439969 taraneh moini zanjani department of pharmacology, shahid beheshti university, tehran, ir iran masoumeh sabetkasaei department of pharmacology, shahid beheshti university, tehran, ir iran

conclusions vpa and cbz treatments caused a decrease in β-catenin and vegf levels in sw480 colon cancer cell lines. these results suggest that cbz can be considered a potential antitumor drug with potencies different from vpa. methods in the present experimental study, implemented during 2014 - 2015 in iran, after incubation of cells into 96-well plates with 5,500 cells/well, the tested drugs w...

Journal: :iranian red crescent medical journal 0
ladan akbarzadeh department of pharmacology, shahid baheshti university of medical sciences, tehran, ir iran; department of pharmacology, shahid baheshti university of medical sciences, tehran, ir iran. fax: +98-22439969 taraneh moini zanjani department of pharmacology, shahid baheshti university of medical sciences, tehran, ir iran masoumeh sabetkasaei department of pharmacology, shahid baheshti university of medical sciences, tehran, ir iran yalda khazaei department of pharmacology, shahid baheshti university of medical sciences, tehran, ir iran

conclusions the results of this study suggest that app reduction by hdacis can apparently play an important role in the treatment of colon cancer. background amyloid precursor protein (app), which is involved in cell proliferation, is observed to be over expressed in human cancer. thus, it is crucial to investigate its role in cancer and suggest treatment strategies to alter its effects on cell...

Afshin Zarghi, Atefeh Haji Agha Bozorgi

Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...

Journal: :iranian journal of blood and cancer 0
mahdi shahriari department of pediatrics, hematology-oncology branch, amir oncology hospital, shiraz university of medical sciences, shiraz, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) بابک عبدالکریمی babak abdolkarimi سازمان اصلی تایید شده: دانشگاه علوم پزشکی لرستان (lorestan university of medical sciences) fazl saleh department of pediatrics, hematology-oncology branch, amir oncology hospital, shiraz university of medical sciences, shiraz, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (shiraz university of medical sciences) pooria salajeghe department of pediatrics, hematology-oncology branch, aliasghar hospital, iran university of medical sciences, shiraz, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

patients with acute myeloblastic leukemia (aml) with monosomy 7 are a group of patients with refractory aml who have a very poor prognosis. therefore, rationally designed new therapies, including metronomic chemotherapy regimen with histidine deacetylase inhibitors (valporic acid, atra) are being investigated as potential treatments for the population of refractory cases of aml. herein, we repo...

Afshin Zarghi, Atefeh Haji Agha Bozorgi

Histone deacetylase inhibitors have gained a great deal of attention recently for the treatment of cancers and inflammatory diseases. So design of new inhibitors is of great importance in pharmaceutical industries and labs. Creating pharmacophor models in order to design new molecules or search a library for finding lead compounds is of great interest. This approach reduces the overall cost ass...

Journal: :international journal of hematology-oncology and stem cell research 0
ahmad ahmadzadeh health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran elahe khodadi health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran mohammad shahjahani health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran jessika bertacchini department of surgery, medicine, dentistry and morphology, university of modena and reggio emilia, modena, italy tina vosoughi health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran najmaldin saki health research institute, research center of thalassemia and hemoglobinopathy, ahvaz jundishapur university of medical sciences, ahvaz, iran

histone deacetylases (hdacs) are the enzymes causing deacetylation of histone and non-histone substrates. histone deacetylase inhibitors (hdis) are a family of drugs eliminating the effect of hdacs in malignant cells via inhibition of hdacs. due to extensive effects upon gene expression through interference with fusion genes and transcription factors, hdacs cause proliferation and migration of ...

Journal: :Dalton Transactions 2023

The complex [PtCl 2 (cyclohexane-1 R ,2 -diamine)] has been combined in a Pt(IV) molecule with two different bioactive molecules (i.e., the histone deacetylase inhibitor 2-propylpentanoic acid or valproic acid, VPA , and potential antimetastatic...

2005
Osamu Kohashi Akiko Kukita Nagata Zhou Wu Kenji Ogawa Takao Hotokebuchi Takahiro Nakamura Toshio Kukita Takeo Shobuike Kengo Nagata Akiko Kukita

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