We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lym...

a case of primary malignant non-hodgkin's lymphoma of the breast is reported. this is the first well-documented case of breast lymphoma in our institution and also in iran. the diagnosis of primary breast lymphoma requires the presence of lymphomatous infiltration in close ass, tissue in patients with neither previous lymphoma nor concurrent lymphoma in another site. there is no definite c...

A human cell line established in culture from a histiocytic lymphoma patient synthesizes and secretes the monocyte-granulocyte specific enzyme lysozyme. 18 other human cell lines with characteristics of T-lymphocyte, B-lymphocyte, Burkitt's lymphoma, non-Burkitt's lymphoma, myeloma, and bone marrow epithelial cells were not associated with lysozyme. Among murine cell lines, lysozyme was produce...

Cell interaction with extracellular matrix is a crucial event for various biological processes, including tumor progression. Although not exclusively, these interactions are frequently mediated by bidirectional signaling receptors known as integrins. Using a human histiocytic lymphoma-derived cell line (U-937), we evaluated the effects of ECM proteins and their integrin-type receptors in the re...

The numbers of alpha-naphthyl acetate esterase (ANAE)-positive cells (other than T cells) have been counted in 32 specimens of Hodgkin's disease and two specimens of histiocytic lymphoma. The different Rye subtypes of Hodgkin's disease contain varying numbers of enzyme-positive cells, ranging from 1.8-16% in the lymphocyte-predominant form to 39.8-47% in lymphocyte-depleted Hodgkin's disease. T...

The 2008 World Health Organization (WHO) diagnostic criteria of histiocytic and dendritic cell neoplasms from hematopoietic and lymphoid tissues no longer required the absence of clonal B-cell/T-cell receptor gene rearrangements. It is true that the clonal B-cell/T-cell receptor gene rearrangements have been identified in rare cases of histiocytic and dendritic cell neoplasms, such as those wit...

50 years ago (1958) The Rappaport Classification system for lymphomas had recently been introduced (1957). In that scheme, lymphomas were considered either nodular or diffuse and either well differentiated, poorly differentiated, undifferentiated, or mixed. The term histiocytic was introduced based upon the belief that neoplasms of large cells were derived from non-lymphoid cells. It is likely ...

-Terminal deoxynucleotidyl transferase (TdT) was estimated in the tissues of 42 patients with lymphoma, whose cells were also typed by the use of surface markers. Four of the 8 patients with T-cell lymphoma were TdT+ including patients whose lymph nodes showed an undifferentiated or poorly differentiated appearance. The TdTT-cell lymphomas included cases with diffuse histiocytic, Sezary cell, d...

Kikuchi-Fujimoto disease (KFD), also known as Kikuchi’s or histiocytic necrotising lymphadenitis, is a rare and benign medical condition of unknown aetiology. It often misdiagnosed lymphoma systemic lupus erythematosus (SLE), leading to inappropriate investigations delayed treatment. thus important for clinicians be cognizant this when assessing patients with cervical lymphadenopathy.