نتایج جستجو برای: histaminergic

تعداد نتایج: 669  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Anna Y Zecharia Xiao Yu Thomas Götz Zhiwen Ye David R Carr Peer Wulff Bernhard Bettler Alexei L Vyssotski Stephen G Brickley Nicholas P Franks William Wisden

The activity of histaminergic neurons in the tuberomammillary nucleus (TMN) of the hypothalamus correlates with an animal's behavioral state and maintains arousal. We examined how GABAergic inputs onto histaminergic neurons regulate this behavior. A prominent hypothesis, the "flip-flop" model, predicts that increased and sustained GABAergic drive onto these cells promotes sleep. Similarly, beca...

2012
Tomoko Ishizuka Atsushi Yamatodani

Feeding behavior is regulated by a complex interplay of many endogenous substances, such as peptides and neurotransmitters in the central nervous system. Histamine is a neurotransmitter which expresses an anorectic effect on food intake via histamine H(1) receptors. The histaminergic system exists downstream of leptin, a satiety factor secreted from white adipose tissue. Because direct stimulat...

2015
Xiao Yu Zhiwen Ye Catriona M. Houston Anna Y. Zecharia Ying Ma Zhe Zhang David S. Uygun Susan Parker Alexei L. Vyssotski Raquel Yustos Nicholas P. Franks Stephen G. Brickley William Wisden

Histaminergic neurons in the tuberomammilary nucleus (TMN) of the hypothalamus form a widely projecting, wake-active network that sustains arousal. Yet most histaminergic neurons contain GABA. Selective siRNA knockdown of the vesicular GABA transporter (vgat, SLC32A1) in histaminergic neurons produced hyperactive mice with an exceptional amount of sustained wakefulness. Ablation of the vgat gen...

Journal: :Sheng li xue bao : [Acta physiologica Sinica] 2006
F Bergquist M B Dutia

Histaminergic drugs have long been used to treat balance disorders in man, but their mechanisms of action in the vestibular system are poorly understood. In this article we review the current literature on histaminergic neurotransmission in the brain focussing particularly in the brainstem vestibular nuclei, and the role of histamine in brain plasticity during "vestibular compensation", the beh...

Journal: :Alcohol and alcoholism 2015
Sergey M Zimatkin Ekaterina M Phedina

AIMS To clarify the effect of chronic alcohol consumption on the brain histaminergic neurons in rats. METHODS Male Wistar rats were given 20% ethanol as the only source of drinking during 6 months, control rats had a free access to water. The samples of hypothalamus were prepared for light and electron microscopy accompanied by morphometry to examine the brain histaminergic neurons of E2 grou...

Journal: :Journal of Chemical Neuroanatomy 2015
Chinatsu Moriwaki Seiichi Chiba Huixing Wei Taishi Aosa Hirokazu Kitamura Keisuke Ina Hirotaka Shibata Yoshihisa Fujikura

Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histaminergic neurons arise in the posterior mesencephalon during the early embryonic period and gradually develop into two histaminergic substreams around the lateral area of the posterior hypothalamus and the more anterior pe...

Journal: :The Malaysian journal of medical sciences : MJMS 2013
Hiroshi Nakagawa Akio Hiura

The following four possible pathways for itching sensation have been suggested by recent reports. 1) Histaminergic TRPV1-positive pathway: Although histamine-positive nerve fibers cannot strictly be classified as "itch specific" due to their excitation also by pure algogens (making them itch-selective), the existence of a subpopulation of nociceptors responsible for itching is strongly suggeste...

Journal: :Anesthesiology 2011
Tao Luo L Stan Leung

BACKGROUND The brain histaminergic system plays a critical role in maintenance of arousal. Previous studies suggest that histaminergic neurotransmission might be a potential mediator of general anesthetic actions. However, it is not clear whether histaminergic tuberomamillary nucleus (TMN) is necessarily involved in the sedative/hypnotic effects of general anesthetics. METHODS Male Long Evans...

Journal: :Annals of neurology 2015
Philipp O Valko Yury V Gavrilov Mihoko Yamamoto Kristen Finn Hasini Reddy Johannes Haybaeck Serge Weis Thomas E Scammell Christian R Baumann

The need for increased sleep after traumatic brain injury is a common and disabling complaint, yet its etiology is unknown. Previous studies have demonstrated diffuse damage to various hypothalamic systems, but the integrity of the histaminergic tuberomammillary nucleus, a major arousal-promoting system located in the posterior hypothalamus, has never been examined in head trauma patients. Here...

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