Aim of this study was to evaluate the biotransformation of simple phenols after ingestion of edible fruits and mixed food. It was analyzed hippuric acid in urine as biomarker of conjugation in the liver cells of glycine with aromatic phenolic acids such benzoic and salicylic acid from ingested food. Measurement of hippuric acid in urine samples of 10 healthy individuals: 5 female and 5 male wit...

Background: Toluene is a harmful substance still being used as a solvent and catalyst in many industries that can increase the level of urinary hippuric acid (UHA). This study was designed to examine the level of toluene and UHA among workers of industrial site in seven companies in Sidoarjo, Indonesia and to analyze the risk factors for abnormal UHA. Methods: This study was an analytical cross...

BACKGROUND The aims of this study were to determine hippuric acid levels in urine samples, airborne toluene levels, acute and chronic neurological symptoms, and to describe any correlation between urinary hippuric acid and airborne toluene. METHODS The hippuric acid concentration in the urine of 87 paint workers exposed to toluene at work (exposed group), and 87 nonexposed people (control gro...

A simple method for the simultaneous determination of hippuric acid and benzoic acid in urine using reversed-phase high performance liquid chromatography was described. Chromatography was performed on a Nova-Pak C18 (3.9 x 150 mm) column with a mobile phase of mixed solution methanol: water: acetic acid (20:80:0.2) and UV detection at 254 nm. The calibration curve was linear within concentratio...

Nine male volunteers were exposed to 2H8-toluene (200 mg/m3 for two hours during a workload of 50 W) via inspiratory air with the aid of a breathing valve and mouthpiece. Labelled toluene was used to differentiate between hippuric acid originating from exposure to toluene and hippuric acid normally excreted in urine. The total uptake of toluene was 2.2 (standard deviation (SD) 0.2) mmol, or 50%...

At present the view is commonly accepted that hippuric acid is produced chiefly by the kidney in most animals and exclusively by that organ in the dog. This conclusion is based largely on the well known work of Bunge and Schmiedeberg (1) who were able to dem0nstrat.e that hippuric acid was formed when blood containing benzoic acid and glycine was perfused through dog kidney. Furthermore, they f...

In a recent study (1) it was found that the synthesis of hippuric acid is markedly diminished in various diseases of the liver especially those in which jaundice is present. These results are all the more interesting because in spite of the extensive research that has been done on hippuric acid, little attention has hitherto been given to the effect of liver damage. The discovery of Bunge and S...

A method using thin-layer chromatography is described to determine the concentration of hippuric acid, mandelic acid, and phenylglyoxylic acid present in the urine after occupational mixed exposure to toluene and styrene. These substances are known metabolites of toluene and styrene, and therefore the evaluation to mixed exposure to toluene and styrene may be carried out separating these metabo...

the aims of this study were to determine hippuric acid and toluene in urine samples, airborne toluene levels, health effects, and to describe any correlation between specimen samples. seventy-five printing workers exposed to toluene at work (exposed group), and 60 nonexposed people (control group) were studied. study participants were selected from same factories in the different positions. uri...