introduction: there are evidences showing the role of nitric oxide in the opiate reward properties. the role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal ca1 area of rats is also confirmed. it has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of nmda...

introduction: according to previous studies, colchicine causes neuronal destruction and learning depression. in this project, effects of colchicine injection into the ca1 and interaction between colchicine and nitric oxide (no) in this area on the expression of drug-seeking behavior were investigated. methods: wistar rats (250-300 g) were bilaterally cannulated at the ca1 area. colchicine (2-8 ...

Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of N...

Background and Objectives: Study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. In this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (CA1) was examined by the studying the hippocampal tissue. Materials and Methods: Injections of colchicine (1-75 μg/rat, intra- hippocampal CA1) were performed in cannulated male Wistar rat...

background and objectives: study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. in this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (ca1) was examined by the studying the hippocampal tissue. materials and methods: injections of colchicine (1-75 μg/rat, intra- hippocampal ca1) were performed in cannulated male wistar rat...

background: gabaergic interneurons in the hippocampal ca1 area are mutually communicated by gap junctions (gjs) composed of connexin36 (cx36). we examined the role of cx36 in ca1 in manifestation of kindled seizures and hippocampal kindling in rats. methods: quinine, as the specific blocker of cx36, was injected into ca1, and kindled seizures severity was examined 10 min afterward. moreover, qu...

This paper describes a modeling-control paradigm to control the hippocampal output (CA1 response) for the development of hippocampal prostheses. In order to bypass a damaged hippocampal region (e.g., CA3), downstream hippocampal signal (e.g., CA1 responses) needs to be reinstated based on the upstream hippocampal signal (e.g., dentate gyrus responses) via appropriate stimulations to the downstr...

The intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer’s disease (AD) in mice, as typified by the onset within 15 days deficits memory and hippocampal long-term potentiation (LTP) that are prevented blockade adenosine A2A receptors (A2AR). Since A2AR overfunction is sufficient to trigger deficits, we tested if were upregulated synapses before support hypothesis co...

introduction: many studies have shown that amygdala kindling produces synaptic potentiation by induction of changes in the neuronal electrophysiological properties and inward currents both in epileptic focus and in the areas which are in connection with the epileptic focus and have important role in seizure development and progression such as hippocampal ca1 region. however, cellular mechanisms...