objective(s):protective effects of diuretics, particularly of hydrochlorothiazide (hct), for the development of seizure attacksepilepsy have been described in vivo. however, itsthe mechanism of action of hct is unknownneeds to be elucidated. materials and methods: extracellular field potentials were recorded from the ca1- and ca3-subfields of the hippocampus of rats. epileptiform discharges wer...

background: this study compares the clinical characteristics of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mtle-hs) with those who have temporal lobe epilepsy (tle) due to other etiologies.   methods : in this retrospective study all patients with a clinical diagnosis of tle were recruited in a referral outpatient epilepsy clinic at shiraz university of medical scie...

the mechanism by which lead may cause a perturbotion in the nevous system is through the nitric oxide synthase. in this study the effect of lead acetate on the hippocampal constitutive nitric oxide production was studied. the variation in the nitric oxide production may contribute to physiological lead neurotoxicity in vivo. different concentrations of lead acetate (10-9 to 10-6 m), wre added t...

the cholinergic and gabaergic .bers of the medial septal/diagonal band of broca (ms/db) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. in addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. the activity of septal and hippocampal neurons i...

neurogenesis occurs throughout life in several regions of the brain. in this lecture, a new sight for the role of the dentate gyrus and adult hippocampal neurogenesis in anxiety disorders will be discussed. the region that has obtained the most attention for its involvement in the neurogenesis of affective and anxiety disorders are the hippocampal and dentate gyrus. evidence strongly suggests t...

introduction: there are evidences showing the role of nitric oxide in the opiate reward properties. the role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal ca1 area of rats is also confirmed. it has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of nmda...

introduction: according to previous studies, colchicine causes neuronal destruction and learning depression. in this project, effects of colchicine injection into the ca1 and interaction between colchicine and nitric oxide (no) in this area on the expression of drug-seeking behavior were investigated. methods: wistar rats (250-300 g) were bilaterally cannulated at the ca1 area. colchicine (2-8 ...

To solve complex spatial problems like visual scanning and spatial navigation, animals must explore and actively sense an array of environmental stimuli. Recent studies have led to an agreement that the hippocampal formation (HF) is essential to the internal representation of spatial relation in animals. In the present study, neural activity was recorded from the HF of three monkeys, which stee...

introduction: prenatal stress has deleterious effects on the development of the brain and is associated with behavioral and psychosocial problems in childhood and adulthood. this study aimed to determine the protective effect of l-arginine on fetal brain under maternal stress. methods: twenty pregnant wistar rats (weighting 200-230 g) were randomly divided into 4 groups (n=5 for each group). th...

objective(s):to determine the effect of acetylcholine (ach), pilocarpine, and atropine on pain evoked responses of pain excited neurons (pen) and pain inhibited neurons (pin) in hippocampal ca3 region of morphine addicted rats. materials and methods:female wistar rats, weighing between 230-260 g were used in this study. morphine addicted rats were generated by subcutaneous injection of increasi...