objective(s) indigofera tinctoria linn. of fabaceae family is claimed to be useful to control epileptic seizures in the indian system of folkore medicine. this study was designed to evaluate i. tinctoria and to verify the claim. materials and methods seizures were induced in male albino rats with pentylenetetrazole (ptz). the test group animals were administered ethanolic extract of indigofera ...

Objective: To evaluate the antiepileptic activity of aqueous extract of Centella asciatica in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced convulsions. Methods: The anticonvulsant activity of leaves of Centella asciatica (200 mg/kg and 400 mg/kg) in mice was assessed using MES and PTZ induced seizure models. Abolition of tonic hind limb extension (MES and PTZ) and increase in...

OBJECTIVE Sambucus (S) spp. is reported to possess a variety of activities and has been used in traditional medicine for many years. In spite of CNS activity of this genus, nothing is known about the anticonvulsant activity of S. nigra. MATERIALS AND METHODS Anticonvulsant activities of methanolic extracts of bark, fruit and leaf of S. nigra at doses of 250, 500 and 1000 mg kg-1 were determin...

Original Article Context: Cilnidipine, an N-type and L-type calcium channel blocker has been reported to have antihypertensive, renoprotective and neuroprotective effect. In this present study we evaluated anti-epileptic effect of cilnidipine in experimentally induced convulsions in Mice. Aims: To evaluate the anti epileptic effect of cilnidipine. Materials and Methods: Cilnidipine, phenytoin s...

This study evaluated the sedative, and anticonvulsant activities of aqueous (AESM) ethanol (EESM) dried leaf extracts Solenostemon monostachyus. The sedative effect was with ketamine-induced hypnosis (100 mg/kg, i.p.). Also, activity using pentylenetetrazole (PTZ)-induced convulsion (85 i.p.), strychnine-induced (2 i.p.) maximal electroshock (MES)-induced models. AESM (200 p.o.) gave 66.67% pro...

The main moto of the present study is to evaluate anticonvulsant property Ficus carica fruits in Swiss albino mice using Maximal electroshock seizures (MES) model. Animals were divided into 5 groups n=6 each Phenytoin (25 mg/kg i.p) as standard drug. Aqueous extract was given at three doses 250 mg/kg, 500 and 750 p.o. test samples had been one hour prior induction convulsions. reveals that aque...

Desynchronized sleep (DS) in the cat is accompanied by a long-lasting (tonic) constriction of muscle blood vessels (conductance decrease 5-30%), on which are superimposed short-lasting (phasic) vasoconstrictor waves that occur simultaneously with bursts of rapid eye movements and body twitches. Both the tonic and the phasic vasoconstrictions are abolished after regional sympathectomy (conductan...

BACKGROUND Epilepsy is one common neurological disorder requiring newer targets and newer drugs for its efficient management. In the recent days brain renin angiotensin system has gained immense importance because of its involvement in seizure regulation. OBJECTIVE To evaluate and compare antiepileptic activity of different doses olmesartan and telmisartan on MES and PTZ induced seizure model...

Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 ml/kg), diazepam (2 mg/kg) and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ ...