objective: to evaluate the efficacy of modified perihepatic packing (mphp) in reducing the rate of re-bleeding rate after packing removal. methods: this was an experimental study being performed in shiraz animal laboratory. high grade liver parenchymal injury was induced in 30 transgenic australian rabbits which were then divided into two groups. group a (control) included 14 and group b (exper...

BACKGROUND Little is known about the clinical importance of concomitant injuries in polytraumatized patients with high-grade blunt liver injury. A retrospective single-centre study was performed to investigate the safety of non-operative management of liver injury and the impact of concomitant intra- and extra-abdominal injuries on clinical outcome. METHODS Some 183 patients with blunt liver ...

Introduction: In many cultures fasting is recommended as a way to protect and promote health. However, there are few studies on the effects of fasting on organ function and resistance to toxic agents such as drugs. This study was conducted to investigate the effect of short-term periodic fasting on the acetaminophen hepatotoxic effects in mice. Methods: In this...

BACKGROUND Although liver injury scale does not predict need for surgical intervention, a high-grade complex liver injury should alert the physician to expect an increased risk of hepatic complications following trauma. The aim of the current study was to define hepatic related morbidity in patients sustaining high-grade hepatic injuries that could be safely managed non-operatively. PATIENTS ...

results: patients in the case and control groups were similar in age and admission vital signs. during the second operation, the bleeding volumes measured in the case and control groups were 66 ± 27.01 ml and 152 ± 85.4 ml, respectively. there was some pad-induced damage after the removal of the pad in the control group. patients and methods: twenty male patients with grade iv or v liver injuri...

HYPOTHESIS Early risk factors for hepatic-related morbidity in patients undergoing initial nonoperative management of complex blunt hepatic injuries can be accurately identified. DESIGN Multicenter historical cohort. SETTING Seven urban level I trauma centers. PATIENTS Patients from January 2000 through May 2003 with complex (grades 3-5) blunt hepatic injuries not requiring laparotomy in ...

OBJECTIVES The aim of this study was to introduce the concept of non-operative management (NOM) for blunt liver trauma by establishing a protocol and a prospective Liver Trauma Registry in Kuwait. SUBJECTS AND METHODS A prospective Liver Trauma Registry was started in 4 hospitals and it included 117 patients who had sustained blunt liver trauma (94 men and 23 women). Unstable patients were ta...

background: in patients with hepatitis b and c, environmental factors such as smoking and alcohol can cause liver fibrosis progression. but opium effects on liver fibrosis progression are not clear. this study was designed to assess the relationship of opium user and liver fibrosis progression. methods: in this case-control study, sixty patients in hepatitis b group and sixty patients in hepati...

BACKGROUND Major bile leak after blunt liver trauma is rare but challenging. It usually requires endoscopic retrograde cholangiography (ERC) for management. However, there is still lack of specific indications. The aim of this study is to elucidate risk factors for major bile leak and indications for early ERC after blunt liver trauma. METHODS The trauma registry of a level I trauma center in...