Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness. Despite the availability of new and more powerful antibiotics children with Hib meningitis still suffer from high mortality or morbidity. The emergence of multir...

Control 16 Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline MMR 15 Saline Saline Saline Saline MMR MMR Saline Saline Saline Saline Saline Saline Saline Saline Saline TCV 12 Hep B Hep B Hep B Hep B Saline Saline DTaP DTaP DTaP DTaP DTaP Hib Hib Hib Hib 1990s Primate 12 Hep B Hep B Hep B Hep B MMR MMR DTaP DTaP DTaP DTaP DTaP Hib Hib Hib Hib...

H2B H3N-PEPAKSA...PKKGSKKAVTKAQKKD...RKRSRKE SYS...YKVLK ...TGISSK...S...SEASRLAHYNKRSTITSRE...VRL ...AKH...GTKAVTKYTSAK-COO10 20 29 30 42 52 64 75 80 90 98 107 114 120 100 Ar Ph Ph Ac Ar Ph OH Ph Ph Ph Ph Me OH Me Ph Ph Ph Me Me Ph Ph Ac Me/Ac/Bu/Cr Hib/Su/Fo Ac Bu Cr Me Ac Bu Cr Hib Me Ac Bu Cr Ac Bu Cr Me/Ac/Bu Cr/Hib/Ub Me Ac Bu Cr Hib Ac Hib Me/Cr/Hib Su/ Ub / Fo Ph Og Me Ac Hib Su Fo Me/A...

BACKGROUND Several countries have applied the Haemophilus influenzae type b (Hib) rapid assessment tool (RAT) to estimate the burden of Hib disease where resources for hospital- or population-based surveillance are limited. In Vietnam, we used the Hib RAT to estimate the burden of Hib pneumonia and meningitis prior to Hib vaccine introduction. METHODS Laboratory, hospitalization and mortality...

Pharyngeal carriage of Haemophilus influenzae type b (Hib) is important in the transmission of Hib organisms, the pathogenesis of Hib disease, and the development of immunity to the bacterium. The remarkable success of current vaccination programs against Hib has been due in part to the effect of conjugate Hib vaccines in decreasing carriage of Hib. This review explores evidence for this effect...

Haemophilus influenzae type b (Hib) is one of the leading causes of meningitis in developing countries. To establish and evaluate a novel loop-mediated isothermal amplification (LAMP) assay for Hib, we designed a LAMP primer set targeting the Hib-specific capsulation locus. LAMP detected 10 copies of purified DNA in a 60-min reaction. This indicated that the detection limit of LAMP was >100-fol...

Haemophilus influenzae type b (Hib) is the leading cause of meningitis in children < 5 years of age. The majority of cases of Hib occur in infants < 2 years of age. Until recently the only vaccine available against this disease contained the pure polysaccharide (PRP) of Hib (Hib-PRP vaccine). The Hib-PRP vaccine was demonstrated to be efficacious in infants > 18 months of age but not below that...

in children. although its burden is considerably preventable by vaccine, routine vaccination against hib has not been defined in the national immunization program of iran. this study was performed to assess the cost-benefit and cost‑utility of running an hib vaccination program in iran. methods: based on a previous systematic review and meta‑analysis for vaccine efficacy, we estimated the avert...

An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl-ribitol phosphate antibody concentration and avidity before and after a Hib booster in 176 children 2-4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertussi...