Multiple mutations contribute to establish cancers. We have searched for potential oncogenes by screening cDNA libraries derived from gastric cancer cell lines, pancreatic cancer cell lines and glioma cell lines, using retrovirus-mediated expression cloning. Two types of interleukin-3 (IL-3)-dependent cell lines, Ba/F3 and HF6, were transduced wit...

Two different metal-organic frameworks containing 2,5-pyrazinedicarboxylate (PzDC2−) as linker molecule and hexanuclear {Hf6(μ3-O)4(μ3-OH)4} clusters were obtained under solvothermal reaction conditions at 120 °C. Formic acid the solvent leads to formation of Hf-UiO-66-PzDC ([Hf6(μ3-O)4(μ3-OH)4(OH)4(H2O)4(PzDC)4]), while in a water/formic mixture resulted crystallisation Hf-CAU-22-PzDC ([Hf6(μ3...

Porous heterogeneous catalysts play a pivotal role in the chemical industry. Herein a new Hf-based metal-organic framework (Hf-NU-1000) incorporating Hf6 clusters is reported. It demonstrates high catalytic efficiency for the activation of epoxides, facilitating the quantitative chemical fixation of CO2 into five-membered cyclic carbonates under ambient conditions, rendering this material an ex...

An iridium-porphyrin ligand, Ir(TCPP)Cl (TCPP 1⁄4 tetrakis(4-carboxyphenyl)porphyrin), has been utilized to react with HfCl4 to generate a stable Ir(III)-porphyrin metal–organic framework of the formula [(Hf6(m3O)8(OH)2(H2O)10)2(Ir(TCPP)Cl)3]$solvents (Ir-PMOF-1(Hf)), which possesses two types of open cavities (1.9 1.9 1.9 and 3.0 3.0 3.0 nm) crosslinked through orthogonal channels (1.9 1.9 nm)...

Recently, in Journal of the American Chemical Society, Quan et al. presented a novel bifunctional metal-organic layer (MOL) that hierarchically integrated organic photosensitizer eosin Y and 2,2′:6′,2″-terpyridine ligated iron triflate. Under blue light irradiation, self-supporting two-dimensional MOL efficiently catalyzed trifluoromethylative difunctionalization alkenes, including bulky bioact...

The cytotoxic activity and the chemical composition of the dichloromethane/methanol root extract of Linum scabrellum Planchon (Linaceae) were analyzed. Using NMR spectra and mass spectrometry analyses of the extract we identified eight main constituents: oleic acid (1), octadecenoic acid (2), stigmasterol (3), α-amyrin (4), pinoresinol (5), 6 methoxypodophyllotoxin (6), coniferin (7), and 6-met...

The Mexican species GALPHIMIA GLAUCA (Cav.) Kuntze (Malphigiaceae) synthesises a family of sedative and anxiolytic nor-secofriedelanes, designated as galphimines. These active principles accumulate at low concentration in the aerial parts of plants from wild populations. Transformed calluses and cell suspension cultures of this species were established in order to induce a greater production of...

The entire ultraviolet-visible absorption spectrum of benzophenone in water is studied and compared with the same spectrum in gas phase. Five transitions are considered, and the corresponding solvatochromic shifts are obtained and compared to experiment. Using a sequential procedure of Monte Carlo simulations and quantum mechanical calculations, liquid configurations were generated and an avera...

The platelet binding properties of human monoclonal lupus autoantibodies have been studied. These IgM autoantibodies, produced by human X human hybridomas derived from lymphocytes of patients with systemic lupus erythematosus, are known to bind to single-stranded DNA. Four anti-DNA antibodies that express the dominant 16/6 idiotype--HF2-1/17, HF2-18/2, HF2-1/13b, and HF3-16/6--bound to glutaral...