TLR signaling is associated with the transcription of various proinflammatory cytokines, including TNF-α, IL-6, and IL-1β. After transcription, the mRNA of these proinflammatory cytokines needs to be tightly controlled at the posttranscriptional level to achieve an optimal expression. However, the precise mechanism of posttranscriptional regulation is not fully understood. In the current study,...

The renormalization group is the cornerstone of modern theory universality and phase transitions, a powerful tool to scrutinize symmetries organizational scales in dynamical systems. However, its network counterpart particularly challenging due correlations between intertwined scales. To date, explorations are based on hidden geometries hypotheses. Here, we propose Laplacian RG diffusion-based ...

NUCLEAR RIBONUCLEAR PROTEINS hnRNP L, hnRNP A1 and hnRNP M Kenneth J. Dery , Shikha Gaur , Marieta Gencheva, Yun Yen, John E. Shively and Rajesh K. Gaur Division of Immunology, Clinical and Molecular Pharmacology Beckman Research Institute of the City of Hope 1450 E. Duarte Road, Duarte, CA 91010 These authors contributed equally to the research Running title: Alternative splicing of CEACAM1 pr...

When people collaborate, they expect more in return than a simple sum of their efforts. This observation is at the heart so-called public goods game, where participants' contributions are multiplied by an $r$ synergy factor before distributed among group members. However, larger could be effective, which can described factor. To elaborate on possible consequences, this study, we introduce model...

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