OBJECTIVE To evaluate the use of a Na/H exchanger (NHE-1) inhibitor as a cardioprotective adjunct therapy to low-volume resuscitation in two different rat models of traumatic hemorrhagic shock. DESIGN Experimental, prospective study. SETTING Medical center research laboratory. SUBJECTS Sprague Dawley male rats. INTERVENTIONS Series 1: femur fracture was induced in anesthetized rats, fol...

The effects of hetastarch on microvascular fluid flux were determined in anesthetized dogs undergoing extracorporeal life support (ECLS) with a roller pump and membrane oxygenator. ECLS with a lactated Ringer priming solution resulted in a decrease in microvascular protein reflection coefficient and an increase in transvascular protein clearance. Use of a 6% hetastarch priming solution attenuat...

This study was designed to determine whether preoperative administration of 6% hetastarch decreases the incidence and severity of hypotension after spinal anesthesia for cesarean section. Forty nonlaboring ASA class I and II women having nonurgent cesarean sections were randomized to receive either 500 mL of 6% hetastarch plus 1 L lactated Ringer's solution (LR) (n = 20), or 2 L of LR (n = 20) ...

Objective: To compare the use of 6% Hetastarch with Lactated ringer's solution for prevention of hypotension after spinal anesthesia for transurethral resection of the prostate. Methods: In a randomized double blind study, 60 patients who underwent subarachnoid anesthesia for transurethral surgery were divided into two equal groups: group A were given Lactated ringer's solution and group B were...

Although controversy exists concerning the optimal total protein and colloid osmotic pressure that should be maintained during cardiopulmonary bypass (CPB), the primary volume expanders remain albumin and 6% hetastarch. The purpose of this study was to quantify the effect of adding boluses of volume replacement agents under various conditions to total serum protein values during CPB. A standard...

background:: hypercoagulability has been reported in primary brain tumors which can lead to thrombotic complications.hydroxyethyl starch (hetastarch) is a synthetic colloid solution with adverse effects on blood coagulation. the aim of this study was to evaluate the protective effect of hetastarch in reducing thromboembolic events in these patients. materials and methods: in a double-blinded cl...

Hespan (hetastarch), a synthetic colloid, is often used in priming cardiopulmonary bypass circuits. The purpose of this study is to determine the efficacy of adding hetastarch to the prime compared to adding no hetastarch. Twenty-four adult patients undergoing cardiopulmonary bypass received Hespan in the prime, while twenty-nine patients did not. Outcomes were compared using paired t-test, ana...

Hextendt (BioTime, Inc., Berkeley, CA) is a new plasma volume expander containing 6% hetastarch, balanced electrolytes, a lactate buffer, and physiological levels of glucose. In preclinical studies, its use in shock models was associated with an improvement in outcome compared with alternatives, such as albumin or 6% hetastarch in saline. In a prospective, randomized, twocenter study (n 5 120),...

Cerebral air emboli have been implicated in the transient neurological deficits seen in patients after cardiovascular surgery. Since perfluorocarbon emulsions such as FC-43 have greater solubilities for gases compared to plasma, it was decided to investigate their potential in providing protection against transient ischemia produced by such emboli. Forty rabbits were divided into three groups o...