نتایج جستجو برای: hepatocytres

تعداد نتایج: 3  

Journal: :iranian journal of pharmaceutical sciences 0
mahdieh anoush department of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran department of pharmacology and toxicology, school of pharmacy, zanjan university of medical sciences, zanjan, iran mohammad ali eghbal department of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran. drug applied research center, tabriz university of medical sciences, tabriz, iran fatemeh fathiazad department of pharmacognosy, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran hossein hamzeiy adepartment of pharmacology and toxicology, faculty of pharmacy, tabriz university of medical sciences, tabriz, iran. biotechnology research center, tabriz university of medical sciences, tabriz, iran nazli saeedi kouzehkonani drug applied research center, tabriz university of medical sciences, tabriz, iran

overdose of acetaminophen causes severe hepatic necrosis in humans and experimental animals. studies on its hepatotoxicity remain a very active area since some of current data are still uncertain. in this study, freshly isolated rat hepatocytes were used to determine the effects of garlic extract and its component, allicin on the acetaminophen-induced cell cytotoxicity and to compare with the e...

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2012
Miguel A. Lanaspa Christina Cicerchi Gabriela Garcia Nanxing Li Carlos A. Roncal-Jimenez Christopher J. Rivard Brandi Hunter Ana Andrés-Hernando Takuji Ishimoto Laura G. Sánchez-Lozada Jeffrey Thomas Robert S. Hodges Colin T. Mant Richard J. Johnson

Fatty liver (hepatic steatosis) is associated with nucleotide turnover, loss of ATP and generation of adenosine monophosphate (AMP). It is well known that in fatty liver, activity of the AMP-activated kinase (AMPK) is reduced and that its stimulation can prevent hepatic steatosis by both enhancing fat oxidation and reducing lipogenesis. Here we show that another AMP dependent enzyme, AMPD2, has...

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Journal: Iranian Journal of Pharmaceutical Sciences 2009
Fatemeh Fathiazad, Hossein Hamzeiy Mahdieh Anoush Mohammad Ali Eghbal, Nazli Saeedi Kouzehkonani

Overdose of acetaminophen causes severe hepatic necrosis in humans and experimental animals. Studies on its hepatotoxicity remain a very active area since some of current data are still uncertain. In this study, freshly isolated rat hepatocytes were used to determine the effects of garlic extract and its component, allicin on the acetaminophen-induced cell cytotoxicity and to compare with the e...

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