Zearalenone (ZEA) as mycoestrogen is found in human foods and animal feeds. Its estrogenic potency depends on its biotransformation fate. The hepatic biotransformation of ZEA in two species of sturgeon fish (Acipenser persicus and Huso huso) was investigated. ZEA was incubated with the hepatic microsomal and post-mitochondrial sub-fractions in the presence of NADPH and the metabolites were dete...

mycoestrogen zearalenone (zea) is found in human foods and animal feeds. its estrogenic potencymainly depends on its biotransformation fate. the hepatic biotransformation of zea in rainbow trout wasinvestigated in this study. various concentrations of zea were separately incubated with the hepaticmicrosomal and post-mitochondrial sub-fractions in the presence of nadph, and the metabolites wered...

Mycoestrogen zearalenone (ZEA) is found in human foods and animal feeds. Its estrogenic potencymainly depends on its biotransformation fate. The hepatic biotransformation of ZEA in rainbow trout wasinvestigated in this study. Various concentrations of ZEA were separately incubated with the hepaticmicrosomal and post-mitochondrial sub-fractions in the presence of NADPH, and the metabolites wered...

Hepatic biotransformation processes can be modulated by chemical exposure and these alterations can impact the biotransformation of endogenous substrates. Furthermore, chemically mediated alterations in the biotransformation of endogenous steroid hormones have been implicated as a mechanism by which steroid hormone homeostasis can be disrupted. The fungicide ketoconazole has been shown to lower...

HIV-infected patients show a markedly increased risk of delayed hypersensitivity (HS) reactions to potentiated sulfonamide antibiotics (trimethoprim/sulfamethoxazole or TMP/SMX). Some studies have suggested altered SMX biotransformation in HIV infection, but hepatic biotransformation pathways have not been evaluated directly. Systemic lupus erythematosus (SLE) is another chronic inflammatory di...

To improve current bioaccumulation assessment methods, a methodology is developed, applied, and investigated for measuring in vivo biotransformation rates of hydrophobic organic substances in the body (soma) and gastrointestinal tract of the fish. The method resembles the Organisation for Economic Co-operation and Development (OECD) 305 dietary bioaccumulation test but includes reference chemic...

Zearalenone (ZEA) is found in contaminated feeds and its oestrogenic effects depend on its biotransformation fate. The current study aimed to investigate the hepatic biotransformation of ZEA in horse by using freshly isolated hepatocytes and also hepatic subcellular fractions. ZEA was incubated with hepatocytes and hepatic intracellular subfractions in the presence of nicotinamide dinucleotide ...

The ability of herbivores to switch diets is thought to be governed by biotransformation enzymes. To identify potential biotransformation enzymes, we conducted a large-scale study on the expression of biotransformation enzymes in herbivorous woodrats (Neotoma lepida). We compared gene expression in a woodrat population from the Great Basin that feeds on the ancestral diet of juniper to one from...