up-regulation of cd4+cd25+cd127low/- regulatory t cells (tregs) is a new target in the treatment of asthma. human bone marrow mesenchymal stem cells can up-regulate cd4+cd25+cd127low/- regulatory t cells in vitro,  meanwhile, heme oxygenase-1 (ho-1) plays an important role in the development and maintenance of cd4+cd25+ regulatory t cells. however the mechanism has not yet been adequately under...

The interaction of heme with blood serum proteins plays an important role in many physiological and pathological processes involving enzyme activity, gene expression cell proliferation. mechanisms underlying these interactions are; however, not yet fully understood. New analytical methods able to investigate protein-heme binding native, biologically representative conditions are thus required. ...

Abstract Under hemolytic conditions, toxic heme is scavenged by hemopexin. Recently, the heme-binding properties of hemopexin have been reassessed, which revealed a K D ~ 0.32 nM as well stoichiometry one to two molecules binding A 66mer hemopexin-derived peptide that spans over three motifs was used verify earlier suggested heme-recruiting mechanism. Herein, we employed spectroscopic and compu...

Introduction: Iron metabolism was found to be implicated in several cancers. Few epidemiologic studies; focusing on iron intake and lung cancer (LC), reported positive associations between heme iron and red meat. Based on estimates of iron contents in representative foods, we conducted the present study with the aim of analyzing dietary iron and its role on the incidence of LC in Uruguayan men,...

Heme is a double-edged sword. On the one hand, it has pivotal role as prosthetic group of hemoproteins in many biological processes ranging from oxygen transport and storage to miRNA processing. other heme can transiently associate with proteins, thereby regulating biochemical pathways. During hemolysis, excess heme, which released into plasma, bind proteins regulate their activity function. Th...

Introduction: Iron metabolism was found to be implicated in several cancers. Few epidemiologic studies; focusing on iron intake and lung cancer (LC), reported positive associations between heme iron and red meat. Based on estimates of iron contents in representative foods, we conducted the present study with the aim of analyzing dietary iron and its role on the incidence of LC in Uruguayan men,...

Some classes of bacteria within phyla possess protein sensors identified as homologous to the heme domain soluble guanylate cyclase, mammalian NO-receptor. Named H-NOX (Heme-Nitric Oxide or OXygen-binding),...

Heme is an iron-containing complex involved in fundamental cellular functions including oxygen transport. Free heme accumulation blood, during intravascular hemolysis and other pathological conditions, triggers vascular dysfunction, pro-inflammatory, prothrombotic cascade. Studies by May et al present a novel finding that ligand for RAGE binds to the V domain of induces oligomerization. Further...