linezolid (lzd), severed as the first oxazolidinone antibiotic, was active against multidrug-resistant gram-positive strains. lzd can induce thrombocytopenia, anemia and leukocytopenia. currently, reports on pure red cell aplasia (prca) cases induced by lzd are relatively rare [4-7]. in this paper, we reported a patient with prca twice induced by lzd. a 37-year-old man was diagnosed with myelody...

Introduction: The current standard of treatment for locally advanced cancer cervix is cisplatin based concurrent chemo radiation therapy followed by brachytherapy. Concurrent radiotherapy causes acute hematological toxicities, which in turn leads to prolongation therapy. Objective: main purpose our study, was analyze the toxicity cervical patients undergoing or Materials and Methods: This a hos...

Abstarct: Use of herbal medicines prevails in rural and urban areas of the world; especially for treating ailments which allopathic medicines fail to treat. Present study was undertaken for the pharmacological and toxicological evaluation of Mucuna pruriens, Cinnamomum zeylanicum, and Myristica fragrans, alone and in combination. The acute toxicity was studied on mice and sub chronic toxicity a...

It remains to be seen whether S-1 can be a replacement for infusional fluorouracil (5-FU) for advanced gastric cancer (AGC). The aim of this study was to compare the efficacy and safety of S-1 with 5-FU in AGC.PubMed and Cochrane Library were searched. Randomized controlled trials and meta-analyses comparing S-1 with 5-FU for AGC were eligible. Meta-analysis was performed using RevMan 5.2.Seven...

INTRODUCTION Docetaxel is a chemotherapy drug widely prescribed in oncology that recognizes a variety of manufactured generics whose toxicity is increasingly reported. The aim of this study was to compare the toxicities between the original and a generics docetaxel in a Moroccan center. METHODS In a cross sectional study, we enrolled patients treated with docetaxel from the oncology departmen...

NAMPT, an enzyme essential for NAD+ biosynthesis, has been extensively studied as an anticancer target for developing potential novel therapeutics. Several NAMPT inhibitors have been discovered, some of which have been subjected to clinical investigations. Yet, the on-target hematological and retinal toxicities have hampered their clinical development. In this study, we report the discovery of ...

BACKGROUND To conduct a comprehensive review whether chemotherapy to radiotherapy after surgical resection could improve the loco regional control and survival compared with postoperative radiotherapy alone. METHODS A comprehensive search of PubMed for relevant studies comparing patients with advanced squamous cell carcinoma of the head and neck undergoing chemoradiotherapy or radiotherapy al...