نتایج جستجو برای: hematin formation

تعداد نتایج: 527628  

2013
Nguyen Tien Huy Yusuke Shima Atsushi Maeda Tran Thanh Men Kenji Hirayama Ai Hirase Atsuo Miyazawa Kaeko Kamei

Phospholipid membranes are thought to be one of the main inducers of hemozoin formation in Plasmodia and other blood-feeding parasites. The "membrane surrounding hemozoin" has been observed in infected cells but has not been observed in in vitro experiments. This study focused on observing the association of phospholipid membranes and synthetic β-hematin, which is chemically identical to hemozo...

Journal: :Antimicrobial agents and chemotherapy 2007
Nguyen Tien Huy Dinh Thanh Uyen Atsushi Maeda Dai Thi Xuan Trang Tatsuo Oida Shigeharu Harada Kaeko Kamei

Current assays for screening new antimalarials need initiators of beta-hematin formation that require laborious preparation, special devices, and substrates. In this study, based on reduction of heme absorption in beta-hematin formation, we developed a simple colorimetric assay using Tween 20 as an initiator and a microplate reader for high-throughput screening of inhibitors of beta-hematin for...

Journal: :Experimental biology and medicine 2001
A U Orjih

The ferriprotoporphyrin IX (FP) molecules released by intraerythrocytic malaria parasites during hemoglobin digestion are converted to beta-hematin and are stored in the parasites' food vacuoles. It has been demonstrated in cell-free medium that the incorporation of FP into beta-hematin under physiological conditions requires a catalyst from parasite lysates or pre-formed beta-hematin. In the p...

2005
Timothy J. Egan Tebogo E. Mabotha Katherine A. De Villiers Helder M. Marques A. Leed K. DuBay L. M. B. Ursos D. Sears A. C. de Dios P. D. Roepe T. J. Egan R. Hunter C. H. Kaschula H. M. Marques A. Misplon J. C. Walden

During their pathogenic blood stage, malaria parasites invade host erythrocytes where they digest hemoglobin. In the process, they release large quantities of potentially toxic hematin, which they convert to hemozoin. This is an insoluble microcrystalline product. The quinoline antimalarials, such as chloroquine form complexes with hematin and inhibit the formation of synthetic hemozoin (β-hema...

Journal: :iranian journal of pharmaceutical research 0
mahdi mojarrab novel drug delivery research center, school of pharmacy, kermanshah university of medical sciences, kermanshah, i.r.iran. rozhin naderi 1)novel drug delivery research center, school of pharmacy, kermanshah university of medical sciences, kermanshah, i.r.iran. 2) student research committee, kermanshah university of medical science, kermanshah, i.r.iran fariba heshmati afshar 3department of traditional pharmacy, faculty of traditional medicine; and medicinal philosophy and history research center, tabriz university of medical sciences, tabriz, i.r. iran

the formation of hemozoin (malaria pigment) has been proposed as an ideal drug target for antimalarial screening programs. in this study, we used an improved, cost-effective and high-throughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. fifteen extracts with different polarity from three iranian artemisia species, a. ciniformis, a. biennis an...

Journal: :Antimicrobial agents and chemotherapy 2006
Saranya Auparakkitanon Soebsakul Chapoomram Kannika Kuaha Thamrong Chirachariyavej Prapon Wilairat

Pyronaridine, 2-methoxy-7-chloro-10[3',5'-bis(pyrrolidinyl-1-methyl-)4'hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine, a new Mannich base schizontocide originally developed in China and structurally related to the aminoacridine drug quinacrine, is currently undergoing clinical testing. We now show that pyronaridine targets hematin, as demonstrated by its ability to inhibit in vitro beta-hemati...

Journal: :Antimicrobial agents and chemotherapy 2003
Richard K Haynes Diego Monti Donatella Taramelli Nicoletta Basilico Silvia Parapini Piero Olliaro

The mechanism of action of artemisinin antimalarials may be ascribed to C-centered radicals that alkylate biomolecules or to the peroxide moiety, which inhibits a specific, as yet undefined, target (4). It is also proposed that artemisinins kill the parasite through inhibition of hemozoin formation, thereby allowing buildup of toxic heme monomer (1, 2, 5). Artemisinin and dihydroartemisinin may...

A Ataei Azimi, B Delnavaz Hashemloian,

Background: β-Hematin (Hemozoin) was synthised inside human erythrocyte by malaria parasite. The parasite avoids the toxic effects by polymerizing heme molecules into insoluble crystalline β-Hematin. C. botrys and A. annua used for the treatment of diseases like malaria, hepatitis, cancers, and inflammations. Objective: Determine of antimalarial and anti-protozoa effects of A. anuuae and C. bo...

Journal: :journal of reports in pharmaceutical sciences 0
mahdi mojarrab marieh rezaei sayyed shahram miraghaee gisya abdi yalda shokoohinia department of pharmacognosy & biotechnology, school of pharmacy, kermanshah 67145-1673, iran

malaria as one of the most recurrent infectious diseases caused by parasites of the genus plasmodium, kills several hundred thousand people especially in the tropical and subtropical regions of the world annually. terpenoids have served as the lead compounds to develop new antimalarial agents. the aromatic monoterpenoid, cuminaldehyde, isolated from the fruits of buniumpersicum was evaluated fo...

2014
Rebecca D. Sandlin Kim Y. Fong Kathryn J. Wicht Holly M. Carrell Timothy J. Egan David W. Wright

The emergence of drug resistant strains of Plasmodium spp. creates a critical need for the development of novel antimalarials. Formation of hemozoin, a crystalline heme detoxification process vital to parasite survival serves as an important drug target. The quinoline antimalarials including chloroquine and amodiaquine owe their antimalarial activity to inhibition of hemozoin formation. Though ...

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