نتایج جستجو برای: hcv core protein
تعداد نتایج: 1442795 فیلتر نتایج به سال:
infection with hepatitis c virus (hcv) is a worldwide problem. among hcv proteins, core antigen (ag), besides its importance for diagnostic application is a prime candidate for component of a vaccine. herein, we report results of studies on production of the hydrophilic domain of core ag (2-122) in native conformation by an arabinose induction system in e.coli and the primary characterization o...
conclusions the canola oilseeds could provide a useful expression system to produce hcv core protein as a vaccine candidate. results western blot analysis using anti-his antibody confirmed the presence of a 15 kda protein in the seeds of t1 transgenic lines. the amount of antigenic protein accumulated in the seeds of these transgenic lines was up to 0.05% of the total soluble protein (tsp). mat...
Background : Hepatitis C virus (HCV) is considered as one of the major pathogenic agents of chronic liver diseases. Previous studies have shown that HCV proteins can interaction with gene regulatory networks such as microRNAs. The aim of this study was to investigate the effect of HCV core protein on the expression of miR-150 in a cell culture model. Materials and Methods: Plasmids expressin...
Background: Hepatitis C virus (HCV) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (HCC). Vaccination based on HCV capsid proteins has attracted a special interest for prevention of viral infections. The core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...
Introduction: Hepatitis C virus (HCV) infection is a major public health problem which influences about 170 million people worldwide. Different types of vaccines have been designed using HCV structural proteins to control the viral infection. The core nucleocapsid protein is one of the most conserved proteins and a desirable target for HCV vaccines, especially the protein-based vaccines. In cur...
background: hepatitis c virus (hcv) is a main public health problem causing chronic liver infection and subsequently liver cirrhosis and lethal hepatocellular carcinoma (hcc). vaccination based on hcv capsid proteins has attracted a special interest for prevention of viral infections. the core protein is a basic and evolutionary most conserved protein, which regulates the cellular processes rel...
Background and Aims: The hepatitis C virus (HCV) F protein is a recently described, frameshift product of HCV core encoding sequence. Its function and antigenic properties are unknown. In order to assess the presence of antibodies specific for F protein we characterized specific anti-F antibodies in patients with chronic HCV infection. Methods: The F protein was cloned from the HCV genome....
conclusions there is an as yet unexplained association between hcv and host parameters with unknown mechanisms in patients with chronic hcv infection. the assessments of core aa 70 substitution and polymorphisms near the ifnl3 gene could offer promising steps to improve the management of patients with hcv. background molecular studies have demonstrated that the hepatitis c virus (hcv) genotype ...
مهمترین عامل هپاتیت non-a, non-b منتقل شونده از راه خون، ویروس هپاتیت c (hcv)است. اندازه ژنوم این ویروس در حدود 6/9 کیلوباز است که در یک قاب خواندنی باز 10 پروتئین را کد می کند. اخیرا گزارش شده است که از قسمت کد کننده hcv-core، پروتئین 17 کیلودالتونی بنام f ترجمه می شود که نقش آن مشخص نشده است اما ممکن است که مانند پروتئین coreبا تاثیر بر سیستم ایمنی نقش احتمالی در پیشرفت بیماری به سمت فاز مز...
conclusions core-lds interaction may be an underlying molecular mechanism to induce liver steatosis in patients with hcv infection. this interaction is also crucial for efficient viral replication and persistence in infected cells. steatosis can also interfere with efficient standard interferon therapy treatment. management of steatosis should be considered along with standard care for achievin...
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