The HCSA (Hybrid Client-Server Architecture), a flexible system layout that combines the advantages of the traditional Client-Server Architecture (CSA) with those of the Shared Disk Architecture (SDA), is introduced. In HCSA, the traditional CSA-style I/O subsystem is modified to give the clients network access to both the server and the server's set of disks. Hence, the HCSA is more fault-tole...

Haemophilus influenzae type b is a common cause of invasive bacterial disease, especially among children in underdeveloped countries. The type b polysaccharide capsule is a polymer of ribose and ribitol-5-phosphate and is a critical determinant of virulence. Expression of the type b capsule is dependent upon the cap b locus, which consists of three functionally distinct regions, designated regi...

Motivation One of the long-expected goals of genome-scale metabolic modelling is to evaluate the influence of the perturbed enzymes on flux distribution. Both ordinary differential equation (ODE) models and constraint-based models, like Flux balance analysis (FBA), lack the capacity to perform metabolic control analysis (MCA) for large-scale networks. Results In this study, we developed a hyp...

Cloud computing requires the security upgrade in data transmission approaches. In general, key-based encryption/decryption (symmetric and asymmetric) mechanisms ensure the secure data transfer between the devices. The symmetric key mechanisms (pseudorandom function) provide minimum protection level compared to asymmetric key (RSA, AES, and ECC) schemes. The presence of expired content and the i...

The polaron band at 1.4 eVof d,l-camphorsulfonic acid-doped polyaniline (( )-HCSA-PANI) in a poly(methyl methacrylate) (PMMA) matrix was studied using electroabsorption (Stark-effect) spectroscopy at 298 K. A very small change in dipole moment on excitation (jDmj) in the order of 1:4 0:2 D was measured as well as an average change in polarizability (Da) of only ÿ1:3 0:4 AÊ . The electroabsorpti...

Moderate hyperhomocysteinemia is associated with several diseases, including coronary artery disease, stroke, Alzheimer's disease, schizophrenia, and spina bifida. However, the mechanisms for their pathogenesis are unknown but could involve the interaction of homocysteine or its metabolites with molecular targets such as neurotransmitter receptors, channels, or transporters. We discovered that ...

Cuckoo search (CS) has been recently proposed as a population-based optimization algorithm and it is has so far been successfully applied in a variety of fields. An efficient hybrid cuckoo search algorithm (HCSA) based on Powell direct search method is proposed for solving constrained engineering design optimization problems. The inertia weight of Levy flights is introduced to balance the abili...

OBJECTIVE to compare the characteristics of cystic fibrosis patients treated in two reference centers in southern Brazil in order to observe trends in the treatment and clinical outcomes that may produce changes in clinical conduct. METHODS cross-sectional, retrospective study with 83 patients diagnosed with cystic fibrosis, aged one month to eighteen years. The variables analyzed were obtain...

One of the long-expected goals of genome-scale metabolic modeling is to evaluate the influence of the perturbed enzymes to the flux distribution. Both ordinary differential equation (ODE) models and the constraint-based models, like Flux balance analysis (FBA), lack of the room of performing metabolic control analysis (MCA) for large-scale networks. In this study, we developed a Hyper-Cube Shri...