The human cytomegalovirus (HCMV) is a global opportunistic β-herpes virus causing severe diseases in immune-compromised patients, such as malignant tumor especially those undergoing chemotherapeutic treatment. This study aimed to determine the prevalence of HCMV-DNA treatment naive cancer and after chemotherapy, compare between conventional nested PCR ELISA techniques for detection HCMV, detect...

Background: Strain-specific antibodies to human cytomegalovirus (HCMV) glycoproteins B and H (gB gH) have been proposed as a potential diagnostic tool for identifying reinfection. We investigated genotype-specific IgG antibody responses in parallel with defining the gB gH genotypes of infecting viral strains. Methods: Subjects primary (n = 20) or non-primary 25) HCMV infection were studied. The...

Background and Aims: Primary infections of rubella and human cytomegalovirus (HCMV) can lead to severe complications in pregnancy. The screening of Rubella and HCMV in pregnant women is not routinely carried out in Iran. This cross sectional study aimed to investigate the seroprevalence of HCMV and rubella infections in neonates with and without congenital defects. Materials and Methods: This s...

Background: Human cytomegalovirus (HCMV) has been detected in tissue samples from patients with glioblastoma but little is known about the systemic immunological response to HCMV these patients. Objectives: To investigate presence and clinical significance of antibodies levels plasma obtained brain tumors. Materials Methods: HCMV-specific IgG IgM antibody were determined 59 collected tumor incl...

Accurate and rapid diagnosis of human cytomegalovirus (HCMV) disease in immunocompromised patients has remained as a challenge. Quantitative competitive PCR (QC-PCR) methods for detection of HCMV in these individuals have improved the positive and negative predictive values of PCR for diagnosis of HCMV disease. In this study we used QC-PCR assay, using a co-amplified DNA standard, to quantitate...

Reactivation and shedding of human cytomegalovirus (HCMV) in breast milk during lactation is highly frequent HCMV-seropositive mothers. This represents a key transmission route for postnatal HCMV infection can lead to severe disease preterm neonates. Little known about strain composition or longitudinal intrahost viral population dynamics from immunocompetent women. We performed HCMV-specific t...

conclusions in this study, high prevalence of 91.7% hcmv gb1 genotype was predominant among hcmv-positive uc patients, which suggests that there might be an association between hcmv gb genotype 1 and uc disease. results among 98 patients with uc, only 12 (12.2%) patients were positive for hcmv genome, while the hcmv genome was not detected in any of the controls. (p = 0.002). the distribution o...

background and aims: primary infections of rubella and human cytomegalovirus (hcmv) can lead to severe complications in pregnancy. the screening of rubella and hcmv in pregnant women is not routinely carried out in iran. this cross sectional study aimed to investigate the seroprevalence of hcmv and rubella infections in neonates with and without congenital defects. materials and methods: this s...