Canonical isoforms in different databases have been defined as the most prevalent, most conserved, most expressed, longest, or the one with the clearest description of domains or posttranslational modifications. In this article, we revisit these definitions of canonical isoforms based on functional genomics and proteomics evidence, focusing on mouse data. We report a novel functional relationsh...

Risk assessment for climate-sensitive systems often relies on the analysis of several variables measured at many sites. In probabilistic terms, task is to model joint distribution spatially distributed variables, and how it varies in time. This paper describes a Bayesian hierarchical framework this purpose. Each variable follows with parameters varying both space Temporal variability modeled by...

Healthcare-associated infections (HCIs) continue to affect patient morbidity and mortality and contribute to the rising cost of health care. Factors associated with the rise of HCIs in patients with cancer may include an increase in antimicrobial resistance and treatment effects of radiation and chemotherapeutic agents. Infection control and prevention practices can decrease infection rates amo...

Alternative splicing allows a single gene to produce multiple transcript-level splice isoforms from which the translated proteins may show differences in their expression and function. Identifying the major functional or canonical isoform is important for understanding gene and protein functions. Identification and characterization of splice isoforms is a stated goal of the HUPO Human Proteome ...

Abstract Hyperfine structures of highly charged ions (HCIs) are favourable spectroscopic targets for exploring fundamental physics along with nuclear properties. Recent proposals HCI atomic clocks highlight their importance, especially many-electron HCIs, and they have been theoretically investigated by refining atomic-structure calculations. However, developments in hyperfine spectroscopy HCIs...

BACKGROUND We introduced a hypometabolic convergence index (HCI) to characterize in a single measurement the extent to which a person's fluorodeoxyglucose positron emission tomogram (FDG PET) corresponds to that in Alzheimer's disease (AD). Apolipoprotein E ε4 (APOE ε4) gene dose is associated with three levels of risk for late-onset AD. We explored the association between gene dose and HCI in ...

It has recently been demonstrated that slow (v << 1 a.u.) highly charged ions (HCIs) are able to generate nano-sized hillocks on cleaved CaF2(1 1 1) surfaces. The aim of the present study was to explore whether surface nanostructures can also be formed on other target materials by the impact of slow HCIs. To this purpose, we have irradiated LiF(0 0 1), diamond-like carbon (DLC) and Au(1 1 1) wi...

Human-computer interfaces (HCIs) have become ubiquitous. Interfaces such as keyboards and mouses are used daily while interacting with computing devices (Ebrahimi et al., 2003). There is a developing need, however, for HCIs that can be used in situations where these typical interfaces are not viable. Direct brain-computer interfaces (BCI) is a developing field that has been adding this new dime...

This paper deals with modeling heterogeneous volumetric objects as point sets with attributes using trivariate B-splines. In contrast to homogeneous volumes with uniform distribution of material and other properties, a heterogeneous volumetric object has a number of variable attributes assigned at each point. An attribute is a mathematical model of an object property of arbitrary nature (materi...

Accurate evaluation of healthcare information systems (HCIS) relies upon the choice of appropriate indicators. Iranian healthcare and health industry professionals were surveyed, by means of a descriptive cross sectional study, in order to identify the indicators they considered most relevant to the evaluation of healthcare information systems currently in use in Iran. It was concluded that eff...